Resolution of Inflammation in Acute Graft-Versus-Host-Disease: Advances and Perspectives
1
Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil
2
Departamento de Enfermagem Básica, Escola de Enfermagem, Universidade Federal de Minas Gerais, Belo Horizonte 30130-100, Brazil
3
Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, and Center for Advanced and Innovative Therapies, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil
*
Author to whom correspondence should be addressed.
Academic Editor: Elena Monica Borroni
Biomolecules 2022, 12(1), 75; https://doi.org/10.3390/biom12010075
Received: 16 November 2021
/
Revised: 21 December 2021
/
Accepted: 29 December 2021
/
Published: 5 January 2022
(This article belongs to the Special Issue New Insights into the Regulation of Inflammation: Mechanisms, Mediators and Therapeutic Targeting)
Inflammation is an essential reaction of the immune system to infections and sterile tissue injury. However, uncontrolled or unresolved inflammation can cause tissue damage and contribute to the pathogenesis of various inflammatory diseases. Resolution of inflammation is driven by endogenous molecules, known as pro-resolving mediators, that contribute to dampening inflammatory responses, promoting the resolution of inflammation and the recovery of tissue homeostasis. These mediators have been shown to be useful to decrease inflammatory responses and tissue damage in various models of inflammatory diseases. Graft-versus-host disease (GVHD) is a major unwanted reaction following allogeneic hematopoietic stem cell transplantation (allo-HSCT) and is characterized by an exacerbated inflammatory response provoked by antigen disparities between transplant recipient and donor. There is no fully effective treatment or prophylaxis for GVHD. This review explores the effects of several pro-resolving mediators and discusses their potential use as novel therapies in the context of GVHD.
View Full-Text
Keywords:
resolution; inflammation; GVHD; pro-resolving mediators
▼
Show Figures
Figure 1
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
MDPI and ACS Style
Duarte, L.R.F.; Pinho, V.; Rezende, B.M.; Teixeira, M.M. Resolution of Inflammation in Acute Graft-Versus-Host-Disease: Advances and Perspectives. Biomolecules 2022, 12, 75. https://doi.org/10.3390/biom12010075
AMA Style
Duarte LRF, Pinho V, Rezende BM, Teixeira MM. Resolution of Inflammation in Acute Graft-Versus-Host-Disease: Advances and Perspectives. Biomolecules. 2022; 12(1):75. https://doi.org/10.3390/biom12010075
Chicago/Turabian StyleDuarte, Layara Roberta Ferreira, Vanessa Pinho, Barbara Maximino Rezende, and Mauro Martins Teixeira. 2022. "Resolution of Inflammation in Acute Graft-Versus-Host-Disease: Advances and Perspectives" Biomolecules 12, no. 1: 75. https://doi.org/10.3390/biom12010075
Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.
