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Commentary

Fibrates: A Possible Treatment Option for Patients with Abdominal Aortic Aneurysm?

Department of Cardiovascular Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan
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Author to whom correspondence should be addressed.
Academic Editor: Vladimir N. Uversky
Biomolecules 2022, 12(1), 74; https://doi.org/10.3390/biom12010074
Received: 26 November 2021 / Revised: 2 January 2022 / Accepted: 3 January 2022 / Published: 5 January 2022
Abdominal aortic aneurysm (AAA) is a life-threatening disease; however, there is no established treatment for patients with AAA. Fibrates are agonists of peroxisome proliferator-activated receptor alpha (PPARα) that are widely used as therapeutic agents to treat patients with hypertriglyceridemia. They can regulate the pathogenesis of AAA in multiple ways, for example, by exerting anti-inflammatory and anti-oxidative effects and suppressing the expression of matrix metalloproteinases. Previously, basic and clinical studies have evaluated the effects of fenofibrate on AAA. In this paper, we summarize the results of these studies and discuss the problems associated with using fenofibrate as a therapeutic agent for patients with AAA. In addition, we discuss a new perspective on the regulation of AAA by PPARα agonists. View Full-Text
Keywords: abdominal aortic aneurysm; fibrates; peroxisome proliferator-activated receptor alpha; macrophages; oxidative stress; matrix metalloproteinase abdominal aortic aneurysm; fibrates; peroxisome proliferator-activated receptor alpha; macrophages; oxidative stress; matrix metalloproteinase
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MDPI and ACS Style

Amioka, N.; Miyoshi, T. Fibrates: A Possible Treatment Option for Patients with Abdominal Aortic Aneurysm? Biomolecules 2022, 12, 74. https://doi.org/10.3390/biom12010074

AMA Style

Amioka N, Miyoshi T. Fibrates: A Possible Treatment Option for Patients with Abdominal Aortic Aneurysm? Biomolecules. 2022; 12(1):74. https://doi.org/10.3390/biom12010074

Chicago/Turabian Style

Amioka, Naofumi, and Toru Miyoshi. 2022. "Fibrates: A Possible Treatment Option for Patients with Abdominal Aortic Aneurysm?" Biomolecules 12, no. 1: 74. https://doi.org/10.3390/biom12010074

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