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Tissue-Specific Landscape of Metabolic Dysregulation during Ageing

Gottfried Schatz Research Center for Cell Signaling, Metabolism and Ageing, Molecular Biology and Biochemistry, Medical University of Graz, 8010 Graz, Austria
Otto-Loewi Research Center, Physiological Chemistry, Medical University of Graz, 8010 Graz, Austria
BioTechMed-Graz, 8010 Graz, Austria
Author to whom correspondence should be addressed.
Academic Editors: Anna Hernández-Aguilera, Fernández-Arroyo Salvador, Nuria Canela and Jorge Joven
Biomolecules 2021, 11(2), 235;
Received: 6 December 2020 / Revised: 22 January 2021 / Accepted: 2 February 2021 / Published: 7 February 2021
(This article belongs to the Special Issue Metabolomics and Integrated Multi-Omics in Health and Disease)
The dysregulation of cellular metabolism is a hallmark of ageing. To understand the metabolic changes that occur as a consequence of the ageing process and to find biomarkers for age-related diseases, we conducted metabolomic analyses of the brain, heart, kidney, liver, lung and spleen in young (9–10 weeks) and old (96–104 weeks) wild-type mice [mixed genetic background of 129/J and C57BL/6] using NMR spectroscopy. We found differences in the metabolic fingerprints of all tissues and distinguished several metabolites to be altered in most tissues, suggesting that they may be universal biomarkers of ageing. In addition, we found distinct tissue-clustered sets of metabolites throughout the organism. The associated metabolic changes may reveal novel therapeutic targets for the treatment of ageing and age-related diseases. Moreover, the identified metabolite biomarkers could provide a sensitive molecular read-out to determine the age of biologic tissues and organs and to validate the effectiveness and potential off-target effects of senolytic drug candidates on both a systemic and tissue-specific level. View Full-Text
Keywords: ageing; tissue-specific; metabolomics; biomarker ageing; tissue-specific; metabolomics; biomarker
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MDPI and ACS Style

Zhang, F.; Kerbl-Knapp, J.; Akhmetshina, A.; Korbelius, M.; Kuentzel, K.B.; Vujić, N.; Hörl, G.; Paar, M.; Kratky, D.; Steyrer, E.; Madl, T. Tissue-Specific Landscape of Metabolic Dysregulation during Ageing. Biomolecules 2021, 11, 235.

AMA Style

Zhang F, Kerbl-Knapp J, Akhmetshina A, Korbelius M, Kuentzel KB, Vujić N, Hörl G, Paar M, Kratky D, Steyrer E, Madl T. Tissue-Specific Landscape of Metabolic Dysregulation during Ageing. Biomolecules. 2021; 11(2):235.

Chicago/Turabian Style

Zhang, Fangrong, Jakob Kerbl-Knapp, Alena Akhmetshina, Melanie Korbelius, Katharina B. Kuentzel, Nemanja Vujić, Gerd Hörl, Margret Paar, Dagmar Kratky, Ernst Steyrer, and Tobias Madl. 2021. "Tissue-Specific Landscape of Metabolic Dysregulation during Ageing" Biomolecules 11, no. 2: 235.

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