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Review

When Order Meets Disorder: Modeling and Function of the Protein Interface in Fuzzy Complexes

1
CNRS, Laboratoire de Biochimie Théorique, UPR9080, Université de Paris, 13 Rue Pierre et Marie Curie, 75005 Paris, France
2
Institut de Biologie Physico-Chimique, Fondation Edmond de Rothschild, PSL Research University, 75006 Paris, France
*
Author to whom correspondence should be addressed.
Academic Editors: Nathalie Sibille, Sonia Longhi and Carine Van Heijenoort
Biomolecules 2021, 11(10), 1529; https://doi.org/10.3390/biom11101529
Received: 14 September 2021 / Revised: 11 October 2021 / Accepted: 12 October 2021 / Published: 16 October 2021
The degree of proteins structural organization ranges from highly structured, compact folding to intrinsic disorder, where each degree of self-organization corresponds to specific functions: well-organized structural motifs in enzymes offer a proper environment for precisely positioned functional groups to participate in catalytic reactions; at the other end of the self-organization spectrum, intrinsically disordered proteins act as binding hubs via the formation of multiple, transient and often non-specific interactions. This review focusses on cases where structurally organized proteins or domains associate with highly disordered protein chains, leading to the formation of interfaces with varying degrees of fuzziness. We present a review of the computational methods developed to provide us with information on such fuzzy interfaces, and how they integrate experimental information. The discussion focusses on two specific cases, microtubules and homologous recombination nucleoprotein filaments, where a network of intrinsically disordered tails exerts regulatory function in recruiting partner macromolecules, proteins or DNA and tuning the atomic level association. Notably, we show how computational approaches such as molecular dynamics simulations can bring new knowledge to help bridging the gap between experimental analysis, that mostly concerns ensemble properties, and the behavior of individual disordered protein chains that contribute to regulation functions. View Full-Text
Keywords: intrinsically disordered proteins; molecular modeling; fuzzy complexes; disorder and function intrinsically disordered proteins; molecular modeling; fuzzy complexes; disorder and function
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MDPI and ACS Style

Sacquin-Mora, S.; Prévost, C. When Order Meets Disorder: Modeling and Function of the Protein Interface in Fuzzy Complexes. Biomolecules 2021, 11, 1529. https://doi.org/10.3390/biom11101529

AMA Style

Sacquin-Mora S, Prévost C. When Order Meets Disorder: Modeling and Function of the Protein Interface in Fuzzy Complexes. Biomolecules. 2021; 11(10):1529. https://doi.org/10.3390/biom11101529

Chicago/Turabian Style

Sacquin-Mora, Sophie, and Chantal Prévost. 2021. "When Order Meets Disorder: Modeling and Function of the Protein Interface in Fuzzy Complexes" Biomolecules 11, no. 10: 1529. https://doi.org/10.3390/biom11101529

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