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Open AccessEditorial

H2S, Polysulfides, and Enzymes: Physiological and Pathological Aspects

by Noriyuki Nagahara 1,*,† and Maria Wróbel 2,*,†
1
Nippon Medical School, Isotope Research Institute, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan
2
Faculty of Medicine, Jagiellonian University Medical College, Kopernika 7 Cracow, 31-034 Krakow, Poland
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this paper.
Biomolecules 2020, 10(4), 640; https://doi.org/10.3390/biom10040640
Received: 10 April 2020 / Accepted: 17 April 2020 / Published: 21 April 2020
We have been studying the general aspects of the functions of H2S and polysulfides, and the enzymes involved in their biosynthesis, for more than 20 years. Our aim has been to elucidate novel physiological and pathological functions of H2S and polysulfides, and unravel the regulation of the enzymes involved in their biosynthesis, including cystathionine β-synthase (EC 4.2.1.22), cystathionine γ-lyase (EC 4.4.1.1), thiosulfate sulfurtransferase (rhodanese, EC 2.8.1.1), and 3-mercaptopyruvate sulfurtransferase (EC 2.8.1.2). Physiological and pathological functions, alternative biosynthetic processes, and additional functions of H2S and polysulfides have been reported. Further, the structure and reaction mechanisms of related enzymes have also been reported. We expect this issue to advance scientific knowledge regarding the detailed functions of H2S and polysulfides as well as the general properties and regulation of the enzymes involved in their metabolism. We would like to cover four topics: the physiological and pathological functions of H2S and polysulfides, the mechanisms of the biosynthesis of H2S and polysulfides, the properties of the biosynthetic enzymes, and the regulation of enzymatic activity. The knockout mouse technique is a useful tool to determine new physiological functions, especially those of H2S and polysulfides. In the future, we shall take a closer look at symptoms in the human congenital deficiency of each enzyme. Further studies on the regulation of enzymatic activity by in vivo substances may be the key to finding new functions of H2S and polysulfides. View Full-Text
Keywords: cystathionine β-synthase; cystathionine γ-lyase; thiosulfate sulfurtransferase; H2S; 3-mercaptopyruvate sulfurtransferase; polysulfides cystathionine β-synthase; cystathionine γ-lyase; thiosulfate sulfurtransferase; H2S; 3-mercaptopyruvate sulfurtransferase; polysulfides
MDPI and ACS Style

Nagahara, N.; Wróbel, M. H2S, Polysulfides, and Enzymes: Physiological and Pathological Aspects. Biomolecules 2020, 10, 640.

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