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Open AccessArticle

Eicosanoid Profile of Influenza A Virus Infected Pigs

1
Institute of Biochemistry, University of Greifswald, 17487 Greifswald, Germany
2
Friedrich-Loeffler-Institute, Suedufer 10, 17493 Greifswald, Germany
3
Lipidomix, 13125 Berlin, Germany
*
Author to whom correspondence should be addressed.
Metabolites 2019, 9(7), 130; https://doi.org/10.3390/metabo9070130
Received: 28 May 2019 / Revised: 28 June 2019 / Accepted: 28 June 2019 / Published: 3 July 2019
(This article belongs to the Special Issue Recent Advances in Metabolomics (IECM-3))
Respiratory tract infections caused by the Influenza A virus (IAV) are a worldwide problem for human and animal health. Within this study, we analyzed the impact of IAV infection on the immune-related lipidome (eicosanoids) of the pig as new infection model. For this purpose, we performed HPLC-MS/MS using dynamic multiple reaction monitoring and analyzed lung, spleen, blood plasma and bronchoalveolar lavages. IAV infection leads to collective changes in the levels of the analyzed hydroxyeicosatrienoic acids (HETEs), hydroxydocosahexaenoic acids (HDHAs) and epoxyeicosatrienoic acids (EETs), and moreover, unique eicosanoid changes in several sample types, even under mild infection conditions. In accordance with different mouse infection studies, we observed infection-related patterns for 12-HETE, 15-HETE and 17-HDHA, which seem to be common for IAV infection. Using a long-term approach of 21 days we established an experimental setup that can be used also for bacterial-viral coinfection experiments. View Full-Text
Keywords: eicosanoids; lipid mediator; Influenza A virus; infection; pig eicosanoids; lipid mediator; Influenza A virus; infection; pig
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MDPI and ACS Style

Schultz, D.; Methling, K.; KoInfekt Study Group; Rothe, M.; Lalk, M. Eicosanoid Profile of Influenza A Virus Infected Pigs. Metabolites 2019, 9, 130.

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