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Metabolites 2012, 2(3), 614-631;

What mRNA Abundances Can Tell us about Metabolism

Institute for Biochemistry, Charité University Medicine Berlin, Charitéplatz 1, Berlin 10117, Germany
Received: 1 August 2012 / Revised: 24 August 2012 / Accepted: 4 September 2012 / Published: 12 September 2012
(This article belongs to the Special Issue Metabolism and Systems Biology)
Full-Text   |   PDF [165 KB, uploaded 12 September 2012]


Inferring decreased or increased metabolic functions from transcript profiles is at first sight a bold and speculative attempt because of the functional layers in between: proteins, enzymatic activities, and reaction fluxes. However, the growing interest in this field can easily be explained by two facts: the high quality of genome-scale metabolic network reconstructions and the highly developed technology to obtain genome-covering RNA profiles. Here, an overview of important algorithmic approaches is given by means of criteria by which published procedures can be classified. The frontiers of the methods are sketched and critical voices are being heard. Finally, an outlook for the prospects of the field is given. View Full-Text
Keywords: transcriptomics; metabolic network; metabolism; metabolic function; Virtual-Liver Network transcriptomics; metabolic network; metabolism; metabolic function; Virtual-Liver Network
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Hoppe, A. What mRNA Abundances Can Tell us about Metabolism. Metabolites 2012, 2, 614-631.

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