Thiopyrano[2,3-d]Thiazoles as New Efficient Scaffolds in Medicinal Chemistry
AbstractThis review presents the up to date development of fused thiopyranothiazoles that comprise one of the thiazolidine derivatives classes. Thiazolidine and thiazolidinone-related compounds belong to the widely studied heterocycles from a medicinal chemistry perspective. From the chemical point of view, they are perfect heterodienes to undergo hetero-Diels–Alder reaction with a variety of dienophiles, yielding regio- and diastereoselectively thiopyranothiazole scaffolds. The annealing of thiazole and thiopyran cycles in condensed heterosystem is a precondition for the “centers conservative” creation of the ligand-target binding complex and can promote a potential selectivity to biotargets. The review covers possible therapeutic applications of thiopyrano[2,3-d]thiazoles, such as anti-inflammatory, antibacterial, anticancer as well as aniparasitic activities. Thus, thiopyrano[2,3-d]thiazoles may be used as powerful tools in the development of biologically active agents and drug-like molecules. View Full-Text
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Kryshchyshyn, A.; Roman, O.; Lozynskyi, A.; Lesyk, R. Thiopyrano[2,3-d]Thiazoles as New Efficient Scaffolds in Medicinal Chemistry. Sci. Pharm. 2018, 86, 26.
Kryshchyshyn A, Roman O, Lozynskyi A, Lesyk R. Thiopyrano[2,3-d]Thiazoles as New Efficient Scaffolds in Medicinal Chemistry. Scientia Pharmaceutica. 2018; 86(2):26.Chicago/Turabian Style
Kryshchyshyn, Anna; Roman, Olexandra; Lozynskyi, Andrii; Lesyk, Roman. 2018. "Thiopyrano[2,3-d]Thiazoles as New Efficient Scaffolds in Medicinal Chemistry." Sci. Pharm. 86, no. 2: 26.
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