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Thiopyrano[2,3-d]Thiazoles as New Efficient Scaffolds in Medicinal Chemistry

Department of Pharmaceutical, Organic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, Pekarska 69, 79010 Lviv, Ukraine
Department of General, Inorganic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, Pekarska 69, 79010 Lviv, Ukraine
Author to whom correspondence should be addressed.
Sci. Pharm. 2018, 86(2), 26;
Received: 22 May 2018 / Revised: 6 June 2018 / Accepted: 7 June 2018 / Published: 14 June 2018


This review presents the up to date development of fused thiopyranothiazoles that comprise one of the thiazolidine derivatives classes. Thiazolidine and thiazolidinone-related compounds belong to the widely studied heterocycles from a medicinal chemistry perspective. From the chemical point of view, they are perfect heterodienes to undergo hetero-Diels–Alder reaction with a variety of dienophiles, yielding regio- and diastereoselectively thiopyranothiazole scaffolds. The annealing of thiazole and thiopyran cycles in condensed heterosystem is a precondition for the “centers conservative” creation of the ligand-target binding complex and can promote a potential selectivity to biotargets. The review covers possible therapeutic applications of thiopyrano[2,3-d]thiazoles, such as anti-inflammatory, antibacterial, anticancer as well as aniparasitic activities. Thus, thiopyrano[2,3-d]thiazoles may be used as powerful tools in the development of biologically active agents and drug-like molecules. View Full-Text
Keywords: 4-thiazolidinones; thiopyrano[2,3-d]thiazoles; [4+2]-cycloaddition; biological activity 4-thiazolidinones; thiopyrano[2,3-d]thiazoles; [4+2]-cycloaddition; biological activity

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Kryshchyshyn, A.; Roman, O.; Lozynskyi, A.; Lesyk, R. Thiopyrano[2,3-d]Thiazoles as New Efficient Scaffolds in Medicinal Chemistry. Sci. Pharm. 2018, 86, 26.

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