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Scientia Pharmaceutica, Volume 84, Issue 4

December 2016 - 15 articles

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Articles (15)

  • Addendum
  • Open Access
2 Citations
2,843 Views
1 Page

2 December 2016

In the published paper [1], the following plant species are listed: Mentha longifolia var. lavanduliodora, Mentha spicata and Mentha spicata var. crispa.[...]

  • Review
  • Open Access
185 Citations
46,405 Views
28 Pages

29 November 2016

The influence of fragrances such as perfumes and room fresheners on the psychophysiological activities of humans has been known for a long time, and its significance is gradually increasing in the medicinal and cosmetic industries. A fragrance consis...

  • Article
  • Open Access
5 Citations
8,054 Views
9 Pages

A Comparative Pharmacokinetics Study of the Anti-Parkinsonian Drug Pramipexole

  • Ratih S. I. Putri,
  • Effi Setiawati,
  • Syifa A. Aziswan,
  • Fenny Ong,
  • Raymond R. Tjandrawinata and
  • Liana W. Susanto

18 November 2016

The present study aimed to compare pharmacokinetic parameters of two pramipexole 0.25 mg formulations in order to show bioequivalence. The study was conducted in a randomized, open-label, two-period, two-sequence, and crossover design, involving 23 h...

  • Article
  • Open Access
7 Citations
4,174 Views
10 Pages

Synthesis, Spatial Structure and Analgesic Activity of Sodium 3-Benzylaminocarbonyl-1-methyl-2,2-dioxo-1H-2λ6,1-benzothiazin-4-olate Solvates

  • Igor V. Ukrainets,
  • Lidiya A. Petrushova,
  • Svitlana V. Shishkina,
  • Lina A. Grinevich and
  • Galina Sim

19 October 2016

In order to obtain and then test pharmocologically any possible conformers of the new feasible analgesic N-benzyl-4-hydroxy-1-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxamide, its 4-O-sodium salt was synthesized using two methods. X-ray diffract...

  • Article
  • Open Access
38 Citations
5,996 Views
9 Pages

Destabilization Mechanism of Ionic Surfactant on Curcumin Nanocrystal against Electrolytes

  • Heni Rachmawati,
  • Annisa Rahma,
  • Loaye Al Shaal,
  • Rainer H. Müller and
  • Cornelia M. Keck

18 October 2016

We have successfully developed curcumin nanosuspension intended for oral delivery. The main purpose is to improve bioavailability through enhancing its solubility. The nanoparticles were stabilized using various stabilizers, including polyvinyl pyrro...

  • Article
  • Open Access
40 Citations
6,595 Views
11 Pages

Effect of Cyclodextrin Types and Co-Solvent on Solubility of a Poorly Water Soluble Drug

  • Suporn Charumanee,
  • Siriporn Okonogi,
  • Jakkapan Sirithunyalug,
  • Peter Wolschann and
  • Helmut Viernstein

18 October 2016

The aim of the study was to investigate the solubility of piroxicam (Prx) depending on the inclusion complexation with various cyclodextrins (CDs) and on ethanol as a co-solvent. The phase-solubility method was applied to determine drug solubility in...

  • Article
  • Open Access
14 Citations
5,691 Views
14 Pages

17 October 2016

A novel, stability indicating, reverse phase high-performance liquid chromatography (RP-HPLC) method was developed to determine the S-isomer of linagliptin (LGP) in linagliptin and metformin hydrochloride (MET HCl) tablets (LGP–MET HCl) by implementi...

  • Article
  • Open Access
5 Citations
6,332 Views
17 Pages

Development and Validation of Miglitol and Its Impurities by RP-HPLC and Characterization Using Mass Spectrometry Techniques

  • Kesavan Balakumaran,
  • Mosesbabu Janagili,
  • Nagaraju Rajana,
  • Sureshbabu Papureddy and
  • Jayashree Anireddy

14 October 2016

Alpha glucoside inhibitors used to treat type-2 diabetes mellitus (DM) are likely to be safe and effective. These agents are most effective for postprandial hyperglycemia. Miglitol is a type of drug used to treat type-2 DM. A simple, selective, linea...

  • Article
  • Open Access
13 Citations
7,297 Views
8 Pages

Evaluation of Certain Pharmaceutical Quality Attributes of Lisinopril Split Tablets

  • Khairi M. S. Fahelelbom,
  • Moawia M. M. Al-Tabakha,
  • Nermin A. M. Eissa and
  • Jeevani Javadi

11 October 2016

Tablet splitting is an accepted practice for the administration of drugs for a variety of reasons, including dose adjustment, ease of swallowing and cost savings. The purpose of this study was to evaluate the physical properties of lisinopril tablets...

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