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Sci. Pharm. 2011, 79(4), 763-778; https://doi.org/10.3797/scipharm.1109-14 (registering DOI)
A Facile Synthesis and Anticancer Activity Evaluation of Spiro[Thiazolidinone-Isatin] Conjugates
Department of Pharmaceutical, Organic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, Pekarska 69, 79010, Lviv, Ukraine
Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Science of Ukraine, Murmanska 1, 02094, Kyiv, Ukraine
Department of Organic Chemistry, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780, Poznań, Poland
Author to whom correspondence should be addressed.
Received: 19 September 2011 / Accepted: 3 October 2011 / Published: 3 October 2011
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Abstract The synthesis and evaluation of the anticancer activity of 3’-aryl-5’-arylidene-spiro[3H-indole-3,2’-thiazolidine]-2,4’(1H)-diones and spiro[3H-indole-3,2’-thi-azolidine]-2,4’(1H)-dione-3’-alkanoic acid esters were described. The structure of the compounds was determined by 1H and 13C NMR and their in vitro anticancer activity was tested in the National Cancer Institute. Among the tested compounds, (5'Z)-5'-(benzylidene)-3'-(4-chlorophenyl)spiro[3H-indole-3,2'-thia-zolidine]-2,4'(1H)-dione (IIa) and (5'Z)-3'-(4-chlorophenyl)-5'-[4-(1-methylethyl)-benzylidene]spiro[3H-indole-3,2'-thiazolidine]-2,4'(1H)-dione (IIb) were superior to other related compounds.
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KAMINSKYY, D.; KHYLUK, D.; VASYLENKO, O.; ZAPRUTKO, L.; LESYK, R. A Facile Synthesis and Anticancer Activity Evaluation of Spiro[Thiazolidinone-Isatin] Conjugates. Sci. Pharm. 2011, 79, 763-778.
KAMINSKYY D, KHYLUK D, VASYLENKO O, ZAPRUTKO L, LESYK R. A Facile Synthesis and Anticancer Activity Evaluation of Spiro[Thiazolidinone-Isatin] Conjugates. Scientia Pharmaceutica. 2011; 79(4):763-778.
KAMINSKYY, Danylo; KHYLUK, Dmytro; VASYLENKO, Olexandr; ZAPRUTKO, Lucjusz; LESYK, Roman. 2011. "A Facile Synthesis and Anticancer Activity Evaluation of Spiro[Thiazolidinone-Isatin] Conjugates." Sci. Pharm. 79, no. 4: 763-778.
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