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Sci. Pharm.
Volume 77
Issue 7
10.3797/scipharm.oephg.21.PO-06
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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Abstract

Docking of Multiple Ligands into a New Homology Model of the Serotonin Transporter

by
R. WEISSENSTEINER
1,*,
H. H. SITTE
2,
M. FREISSMUTH
2 and
G. F. ECKER
1
1
Department of Medicinal Chemistry, University of Vienna, Althanstraße 14, 1090 Wien, Austria
2
Department of Pharmacology, Medical University of Vienna, Währingerstrße 13a, 1090 Wien, Austria
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2009, 77(7), 205; https://doi.org/10.3797/scipharm.oephg.21.PO-06
Submission received: 16 April 2009 / Accepted: 16 April 2009 / Published: 16 April 2009
Versions Notes

Abstract

The serotonin transporter (SERT) is a presynaptic membrane protein that terminates neuronal transmission of serotonin (5HT) by transporting its substrate into the emitting neuron. Recently new crystal structures of the Leucine Transporter (LeuT) with multiple bound ligands have been published [1]. LeuT is a bacterial sodium dependent amino acid transporter, which is a homologue of the mammalian neurotransmitter sodium symporter (NSS) family (tcdb-code 2.A.22, www.tcdb.org), such as SERT. In light of our studies on the molecular basis of inhibitor binding we constructed a new homology model of SERT and used this for docking studies of a series of pharmacologically active ligands.

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MDPI and ACS Style

WEISSENSTEINER, R.; SITTE, H.H.; FREISSMUTH, M.; ECKER, G.F. Docking of Multiple Ligands into a New Homology Model of the Serotonin Transporter. Sci. Pharm. 2009, 77, 205. https://doi.org/10.3797/scipharm.oephg.21.PO-06

AMA Style

WEISSENSTEINER R, SITTE HH, FREISSMUTH M, ECKER GF. Docking of Multiple Ligands into a New Homology Model of the Serotonin Transporter. Scientia Pharmaceutica. 2009; 77(Posters (PO)):205. https://doi.org/10.3797/scipharm.oephg.21.PO-06

Chicago/Turabian Style

WEISSENSTEINER, R., H. H. SITTE, M. FREISSMUTH, and G. F. ECKER. 2009. "Docking of Multiple Ligands into a New Homology Model of the Serotonin Transporter" Scientia Pharmaceutica 77, Posters (PO): 205. https://doi.org/10.3797/scipharm.oephg.21.PO-06

APA Style

WEISSENSTEINER, R., SITTE, H. H., FREISSMUTH, M., & ECKER, G. F. (2009). Docking of Multiple Ligands into a New Homology Model of the Serotonin Transporter. Scientia Pharmaceutica, 77(Posters (PO)), 205. https://doi.org/10.3797/scipharm.oephg.21.PO-06

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