Expression of Sulfotransferases and Sulfatases in Human Breast Cancer: Impact on Resveratrol Metabolism

M. MIKSITS; K. WLCEK; M. SVOBODA; T. THALHAMMER; W. JÄGER

doi:10.3797/scipharm.oephg.21.SL-30

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Abstract

16 April 2009

Expression of Sulfotransferases and Sulfatases in Human Breast Cancer: Impact on Resveratrol Metabolism

and

Department of Clinical Pharmacy and Diagnostics, University of Vienna, Althanstraße 14, A-1090, Vienna, Austria

Center for Physiology and Pathophysiology, Medical University of Vienna, Währinger Gürtel 18-20, A-1090, Vienna, Austria

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Sci. Pharm.2009, 77(6), 197;https://doi.org/10.3797/scipharm.oephg.21.SL-30

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Abstract

Resveratrol is a naturally occurring anticancer compound present in grapes and wine that undergoes pronounced metabolism in human intestine and liver. In order to determine whether resveratrol is also biotransformed in human breast carcinoma, metabolism experiments were conducted in breast tumor and adjacent non-tumorous specimens from 13 patients. Resveratrol was metabolized in cytosolic tissue fractions to resveratrol-3-O-sulfate: the formation rates were up to 33.5-fold higher in cancer samples than in peritumoral tissue.

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