Next Article in Journal
Austrian Red Wine Samples Reveal Enhanced Activity of the Enzyme Endothelial Nitric Oxide Synthase
Previous Article in Journal
Expression of Organic Anion Transporter Polypeptides (OATPs) in Human Breast Carcinoma
Article Menu

Article Versions

Export Article

Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
Open AccessAbstract
Sci. Pharm. 2009, 77(Short Lectures (SL)), 197; (registering DOI)

Expression of Sulfotransferases and Sulfatases in Human Breast Cancer: Impact on Resveratrol Metabolism

Department of Clinical Pharmacy and Diagnostics, University of Vienna, Althanstraße 14, A-1090, Vienna, Austria
Center for Physiology and Pathophysiology, Medical University of Vienna, Währinger Gürtel 18-20, A-1090, Vienna, Austria
Author to whom correspondence should be addressed.
Received: 16 April 2009 / Accepted: 16 April 2009 / Published: 16 April 2009
PDF [199 KB, uploaded 12 May 2017]


Resveratrol is a naturally occurring anticancer compound present in grapes and wine that undergoes pronounced metabolism in human intestine and liver. In order to determine whether resveratrol is also biotransformed in human breast carcinoma, metabolism experiments were conducted in breast tumor and adjacent non-tumorous specimens from 13 patients. Resveratrol was metabolized in cytosolic tissue fractions to resveratrol-3-O-sulfate: the formation rates were up to 33.5-fold higher in cancer samples than in peritumoral tissue.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

MIKSITS, M.; WLCEK, K.; SVOBODA, M.; THALHAMMER, T.; JÄGER, W. Expression of Sulfotransferases and Sulfatases in Human Breast Cancer: Impact on Resveratrol Metabolism. Sci. Pharm. 2009, 77, 197.

Show more citation formats Show less citations formats

Article Metrics

Article Access Statistics



[Return to top]
Sci. Pharm. EISSN 2218-0532 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top