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Sci. Pharm. 2009, 77(Short Lectures (SL)), 196; https://doi.org/10.3797/scipharm.oephg.21.SL-29 (registering DOI)
Expression of Organic Anion Transporter Polypeptides (OATPs) in Human Breast Carcinoma
Department of Clinical Pharmacy and Diagnostics, University of Vienna, Althanstraße 14, 1090, Vienna, Austria
Center for Physiology and Pathophysiology, Medical University of Vienna, General Hospital Vienna, Waehringerguertel 18-20, 1090, Vienna, Austria
Author to whom correspondence should be addressed.
Received: 16 April 2009 / Accepted: 16 April 2009 / Published: 16 April 2009
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Organic anion transporter polypeptides (OATPs) mediate the transmembrane uptake of endogenous compounds and clinically important drugs in various tissues thereby effecting drug disposition and tissue penetration. OATPs have also been identified in gastric, pancreatic, and colon carcinomas but little is known about their expression in breast carcinoma. We therefore analyzed the expression pattern of all 11 known OATPs in three breast cancer cell lines (MCF-7, ZR-75-1, MDA-MB-231) and one immortalized breast epithelial cell line (MCF-10A) using quantitative PCR. Transcripts of 7/11 OATP genes with a remarkable heterogeneity in their expression profile were detected in control and/or cancer cell lines.[...]
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WLCEK, K.; SVOBODA, M.; THALHAMMER, T.; JÄGER, W. Expression of Organic Anion Transporter Polypeptides (OATPs) in Human Breast Carcinoma. Sci. Pharm. 2009, 77, 196.
WLCEK K, SVOBODA M, THALHAMMER T, JÄGER W. Expression of Organic Anion Transporter Polypeptides (OATPs) in Human Breast Carcinoma. Scientia Pharmaceutica. 2009; 77(Short Lectures (SL)):196.
WLCEK, K.; SVOBODA, M.; THALHAMMER, T.; JÄGER, W. 2009. "Expression of Organic Anion Transporter Polypeptides (OATPs) in Human Breast Carcinoma." Sci. Pharm. 77, Short Lectures (SL): 196.
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