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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Sci. Pharm. 2009, 77(Short Lectures (SL)), 196; (registering DOI)

Expression of Organic Anion Transporter Polypeptides (OATPs) in Human Breast Carcinoma

Department of Clinical Pharmacy and Diagnostics, University of Vienna, Althanstraße 14, 1090, Vienna, Austria
Center for Physiology and Pathophysiology, Medical University of Vienna, General Hospital Vienna, Waehringerguertel 18-20, 1090, Vienna, Austria
Author to whom correspondence should be addressed.
Received: 16 April 2009 / Accepted: 16 April 2009 / Published: 16 April 2009
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Note: In lieu of an abstract, this is an excerpt from the first page.


Organic anion transporter polypeptides (OATPs) mediate the transmembrane uptake of endogenous compounds and clinically important drugs in various tissues thereby effecting drug disposition and tissue penetration. OATPs have also been identified in gastric, pancreatic, and colon carcinomas but little is known about their expression in breast carcinoma. We therefore analyzed the expression pattern of all 11 known OATPs in three breast cancer cell lines (MCF-7, ZR-75-1, MDA-MB-231) and one immortalized breast epithelial cell line (MCF-10A) using quantitative PCR. Transcripts of 7/11 OATP genes with a remarkable heterogeneity in their expression profile were detected in control and/or cancer cell lines.[...]
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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WLCEK, K.; SVOBODA, M.; THALHAMMER, T.; JÄGER, W. Expression of Organic Anion Transporter Polypeptides (OATPs) in Human Breast Carcinoma. Sci. Pharm. 2009, 77, 196.

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