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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Sci. Pharm. 2009, 77(Short Lectures (SL)), 187;

Identification of Privileged Atom-Types in Substrates of the ABC-Transporter ABCB1 (P-gp) by Random Forest Classification

Department of Medicinal Chemistry, University of Vienna, Althanstraße 14, 1090, Vienna, Austria
Boehringer Ingelheim RCV GmbH & Co KG, Dr. Boehringer-Gasse 5-11, A-1121, Vienna, Austria
Author to whom correspondence should be addressed.
Received: 16 April 2009 / Accepted: 16 April 2009 / Published: 16 April 2009
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The ABC-transporter ABCB1 (P-glycoprotein) is a drug efflux pump playing an important role in the transport route of drugs through tissue barriers, protection against xenobiotics, and in cancer drug resistance. Due to this, ABCB1 is notorious for limiting bioavailability of various chemical and functional unrelated drugs.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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DEMEL, M.A.; KRÄMER, O.; ETTMAYER, P.; HAAKSMA, E.E.J.; ECKER, G.F. Identification of Privileged Atom-Types in Substrates of the ABC-Transporter ABCB1 (P-gp) by Random Forest Classification. Sci. Pharm. 2009, 77, 187.

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