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Sci. Pharm.
Volume 77
Issue 6
10.3797/scipharm.oephg.21.SL-20
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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Abstract

Identification of Privileged Atom-Types in Substrates of the ABC-Transporter ABCB1 (P-gp) by Random Forest Classification

by
M. A. DEMEL
1,*,
O. KRÄMER
2,
P. ETTMAYER
2,
E. E. J. HAAKSMA
2 and
G. F. ECKER
1
1
Department of Medicinal Chemistry, University of Vienna, Althanstraße 14, 1090, Vienna, Austria
2
Boehringer Ingelheim RCV GmbH & Co KG, Dr. Boehringer-Gasse 5-11, A-1121, Vienna, Austria
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2009, 77(6), 187; https://doi.org/10.3797/scipharm.oephg.21.SL-20
Submission received: 16 April 2009 / Accepted: 16 April 2009 / Published: 16 April 2009
Versions Notes

Abstract

The ABC-transporter ABCB1 (P-glycoprotein) is a drug efflux pump playing an important role in the transport route of drugs through tissue barriers, protection against xenobiotics, and in cancer drug resistance. Due to this, ABCB1 is notorious for limiting bioavailability of various chemical and functional unrelated drugs.

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MDPI and ACS Style

DEMEL, M.A.; KRÄMER, O.; ETTMAYER, P.; HAAKSMA, E.E.J.; ECKER, G.F. Identification of Privileged Atom-Types in Substrates of the ABC-Transporter ABCB1 (P-gp) by Random Forest Classification. Sci. Pharm. 2009, 77, 187. https://doi.org/10.3797/scipharm.oephg.21.SL-20

AMA Style

DEMEL MA, KRÄMER O, ETTMAYER P, HAAKSMA EEJ, ECKER GF. Identification of Privileged Atom-Types in Substrates of the ABC-Transporter ABCB1 (P-gp) by Random Forest Classification. Scientia Pharmaceutica. 2009; 77(Short Lectures (SL)):187. https://doi.org/10.3797/scipharm.oephg.21.SL-20

Chicago/Turabian Style

DEMEL, M. A., O. KRÄMER, P. ETTMAYER, E. E. J. HAAKSMA, and G. F. ECKER. 2009. "Identification of Privileged Atom-Types in Substrates of the ABC-Transporter ABCB1 (P-gp) by Random Forest Classification" Scientia Pharmaceutica 77, Short Lectures (SL): 187. https://doi.org/10.3797/scipharm.oephg.21.SL-20

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