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Sci. Pharm.
Volume 77
Issue 6
10.3797/scipharm.oephg.21.SL-19
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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Abstract

Evaluation of a Blood-Brain Barrier in vitro Model Based on Primary Rat Cells

by
W. NEUHAUS
1,
E. SUBILEAU
2,
C. CHESNE
2,
D. GRUBER
3,
S. TÖGEL
4,
W. KLEPAL
3 and
C. R. NOE
5,*
1
PharmaCon GmbH, Riglergasse 4/5, 1180, Vienna, Austria
2
Biopredic International, 8-18 rue Jean Pecker, 35000, Rennes, France
3
Dep. for Cell Imaging and Ultrastructure Res., University of Vienna, Althanstraße 14, 1090, Vienna, Austria
4
Dep. of Pharm. Techn. and Biopharm., University of Vienna, Althanstraße 14, 1090, Vienna, Austria
5
Dep. of Medicinal Chemistry, University of Vienna, Althanstraße 14, 1090, Vienna, Austria
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2009, 77(6), 186; https://doi.org/10.3797/scipharm.oephg.21.SL-19
Submission received: 16 April 2009 / Accepted: 16 April 2009 / Published: 16 April 2009
Versions Notes

Excerpt

Note: In lieu of an abstract, this is an excerpt from the first page.

The blood-brain barrier (BBB) maintains the homeostasis between the central nervous system and the blood circulation [1]. Until now, no standard in vitro model of the BBB is available. In this contribution a novel BBB in vitro model based on primary rat brain microvasculature endothelial cells (RBMEC) and primary rat glial cells (RGC) is introduced. The cells were isolated from Wistar rats and were provided by the company Biopredic Int. RBMEC were co-cultured with RGC in a 12-well Transwell system. The development of the barrier was monitored by the measurement of the transendothelial electrical resistance (TEER).[...]

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MDPI and ACS Style

NEUHAUS, W.; SUBILEAU, E.; CHESNE, C.; GRUBER, D.; TÖGEL, S.; KLEPAL, W.; NOE, C.R. Evaluation of a Blood-Brain Barrier in vitro Model Based on Primary Rat Cells. Sci. Pharm. 2009, 77, 186. https://doi.org/10.3797/scipharm.oephg.21.SL-19

AMA Style

NEUHAUS W, SUBILEAU E, CHESNE C, GRUBER D, TÖGEL S, KLEPAL W, NOE CR. Evaluation of a Blood-Brain Barrier in vitro Model Based on Primary Rat Cells. Scientia Pharmaceutica. 2009; 77(Short Lectures (SL)):186. https://doi.org/10.3797/scipharm.oephg.21.SL-19

Chicago/Turabian Style

NEUHAUS, W., E. SUBILEAU, C. CHESNE, D. GRUBER, S. TÖGEL, W. KLEPAL, and C. R. NOE. 2009. "Evaluation of a Blood-Brain Barrier in vitro Model Based on Primary Rat Cells" Scientia Pharmaceutica 77, Short Lectures (SL): 186. https://doi.org/10.3797/scipharm.oephg.21.SL-19

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