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Volume 76
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Article

Isolation and Structure Elucidation of Cerebrosides from Euphorbia Platyphyllos L.

by
Francesca CATENI
*,
Jelena ZILIC
and
Marina ZACCHIGNA
Department of Pharmaceutical Sciences, University of Trieste, P.zle Europa, 1, 34127 Trieste, Italy
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2008, 76(3), 451-470; https://doi.org/10.3797/scipharm.0805-03
Submission received: 6 May 2008 / Accepted: 3 September 2008 / Published: 5 September 2008
Versions Notes

Abstract

A new cerebroside (1), together with three known ones (2–4) have been isolated from the whole plants of Euphorbia platyphyllos L. The structures were established by FT-IR spectroscopy, FAB-MS, advanced two-dimensional NMR, including 1H-NMR, 1H,1H-COSY, HMQC and HMBC experiments and chemical reactions. The structures of the cerebrosides were characterized as 1-O-β-D-glycosides of phytosphingosines, which comprised a common long-chain base, (2S,3S,4R,8Z)-2-aminooctadec-8-ene-1,3,4-triol (1–3) and (2S,3S,4E,8E)-2-aminooctadeca-4,8-diene-1,3-diol (4) with 2-hydroxy fatty acids of varying chain lengths (C16, C24, C26:1, C28:1) linked to the amino group. The isolated compounds have been evaluated for their antifungal and antitubercular activities.
Keywords: Euphorbia platyphyllos L.; Cerebrosides; Phytosphingosines; 2-Hydroxy-fatty acids Euphorbia platyphyllos L.; Cerebrosides; Phytosphingosines; 2-Hydroxy-fatty acids

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MDPI and ACS Style

CATENI, F.; ZILIC, J.; ZACCHIGNA, M. Isolation and Structure Elucidation of Cerebrosides from Euphorbia Platyphyllos L. Sci. Pharm. 2008, 76, 451-470. https://doi.org/10.3797/scipharm.0805-03

AMA Style

CATENI F, ZILIC J, ZACCHIGNA M. Isolation and Structure Elucidation of Cerebrosides from Euphorbia Platyphyllos L. Scientia Pharmaceutica. 2008; 76(3):451-470. https://doi.org/10.3797/scipharm.0805-03

Chicago/Turabian Style

CATENI, Francesca, Jelena ZILIC, and Marina ZACCHIGNA. 2008. "Isolation and Structure Elucidation of Cerebrosides from Euphorbia Platyphyllos L." Scientia Pharmaceutica 76, no. 3: 451-470. https://doi.org/10.3797/scipharm.0805-03

APA Style

CATENI, F., ZILIC, J., & ZACCHIGNA, M. (2008). Isolation and Structure Elucidation of Cerebrosides from Euphorbia Platyphyllos L. Scientia Pharmaceutica, 76(3), 451-470. https://doi.org/10.3797/scipharm.0805-03

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