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Sci. Pharm.
Volume 76
Issue 2
10.3797/scipharm.0803-29
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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Article

Rosiglitazone modifies PEDF gene expression and protein levels in the Koletsky rat choroid-RPE complex

by
Jena J. STEINLE
1,2,
Bethany L. LASHBROOK
1 and
William J. BANZ
1,3,*
1
Department of Physiology, Southern Illinois University School of Medicine
2
Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, TN 38163
3
Department of Animal Science, Food and Nutrition, Southern Illinois University, Carbondale, IL 62901
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2008, 76(2), 133-150; https://doi.org/10.3797/scipharm.0803-29
Submission received: 27 March 2008 / Accepted: 16 May 2008 / Published: 21 May 2008
Versions Notes

Abstract

The purpose of this study was to determine whether rosiglitazone, a peroxisome proliferator-activated receptor (PPAR)γ ligand, altered growth factor expression in the choroid-RPE complex of Koletsky rats. Using lean and obese Koletsky rats fed a normal or rosiglitazone-supplemented diet, gene and protein expression of vascular endothelial growth factor (VEGF), pigment epithelial derived growth factor (PEDF), angiopoietin 1, and its receptor, Tie-2, were assessed. Both gene expression and protein expression of PEDF were significantly increased in both obese and lean Koletsky rats treated with rosiglitazone diet. Gene expression of VEGF, angiopoietin-1 and Tie-2 were increased after rosiglitazone treatment, without changes in protein expression. Since PPARγ ligands have been implicated in vascular remodeling, these results suggest that upregulation of PEDF expression may be a potential mechanism in the rat choroid-RPE complex.
Keywords: Choroid; Koletsky; Growth factors; PPAR gamma; RPE Choroid; Koletsky; Growth factors; PPAR gamma; RPE

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MDPI and ACS Style

STEINLE, J.J.; LASHBROOK, B.L.; BANZ, W.J. Rosiglitazone modifies PEDF gene expression and protein levels in the Koletsky rat choroid-RPE complex. Sci. Pharm. 2008, 76, 133-150. https://doi.org/10.3797/scipharm.0803-29

AMA Style

STEINLE JJ, LASHBROOK BL, BANZ WJ. Rosiglitazone modifies PEDF gene expression and protein levels in the Koletsky rat choroid-RPE complex. Scientia Pharmaceutica. 2008; 76(2):133-150. https://doi.org/10.3797/scipharm.0803-29

Chicago/Turabian Style

STEINLE, Jena J., Bethany L. LASHBROOK, and William J. BANZ. 2008. "Rosiglitazone modifies PEDF gene expression and protein levels in the Koletsky rat choroid-RPE complex" Scientia Pharmaceutica 76, no. 2: 133-150. https://doi.org/10.3797/scipharm.0803-29

APA Style

STEINLE, J. J., LASHBROOK, B. L., & BANZ, W. J. (2008). Rosiglitazone modifies PEDF gene expression and protein levels in the Koletsky rat choroid-RPE complex. Scientia Pharmaceutica, 76(2), 133-150. https://doi.org/10.3797/scipharm.0803-29

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