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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).

Sci. Pharm., Volume 76, Issue 1 (March 2008) – 8 articles , Pages 1-100

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167 KiB  
Introduction
Instructions for Authors 2008
by Scientia Pharmaceutica
Sci. Pharm. 2008, 76(1), 91-100; https://doi.org/10.3797/scipharm.aut-08-01 - 30 Mar 2008
Viewed by 829
1894 KiB  
Article
The Influence of Selected Parameters on the Size and Shape of Alginate Beads Prepared by Ionotropic Gelation
by Polona SMRDEL, Marija BOGATAJ and Aleš MRHAR
Sci. Pharm. 2008, 76(1), 77-90; https://doi.org/10.3797/scipharm.0611-07 - 30 Mar 2008
Cited by 116 | Viewed by 3883
Abstract
Many bead biopharmaceutical characteristics are dependent on the bead shape. Furthermore, the shape is one of crucial parameters for incorporation of beads in more complex drug delivery system. Therefore, the aim of this study was to evaluate the influence of various processing parameters [...] Read more.
Many bead biopharmaceutical characteristics are dependent on the bead shape. Furthermore, the shape is one of crucial parameters for incorporation of beads in more complex drug delivery system. Therefore, the aim of this study was to evaluate the influence of various processing parameters such as hardening time, temperature and concentration of calcium chloride solution and drying conditions on size, shape and morphology of alginate beads prepared by ionotropic gelation method. Theophylline was selected as a model drug. It was found that all studied parameters markedly affected bead form, resembling in most cases to ellipsoid spheres. Their sphericity was estimated three-dimensionally by measuring diameters of frontal and lateral side which were perpendicular to each other. Smaller and more spherical beads were obtained at longer hardening time and higher temperature of calcium chloride solution. The freeze-dried beads were the largest and the most spherical. It was demonstrated that optimization of bead shape as well as size and morphology could be achieved by altering processing parameters. Full article
1546 KiB  
Article
Illicium verum Hook. f. and Illicium anisatum L.: Anatomical Characters and their Value for Differentiation
by Elisabeth FRITZ, Silvester M. ÖLZANT and Reinhard LÄNGER
Sci. Pharm. 2008, 76(1), 65-76; https://doi.org/10.3797/scipharm.0802-03 - 30 Mar 2008
Cited by 17 | Viewed by 1752
Abstract
In the last years intoxications after consumption of Illicium verum Hook. f. have been reported due to adulterations with I. anisatum L.. Many efforts have already been made to develop a simple method which would enable the detection of I. anisatum in powdered [...] Read more.
In the last years intoxications after consumption of Illicium verum Hook. f. have been reported due to adulterations with I. anisatum L.. Many efforts have already been made to develop a simple method which would enable the detection of I. anisatum in powdered samples of I. verum. Since many controversial facts concerning the value of anatomic characters for differentiation have been published 13 botanically vouchered samples were re-examined by means of light microscopy, fluorescence microscopy, SEM, and confocal laser scanning microscopy. All anatomical details show a great variability even between the follicles of a certain aggregate. This is also true for the cuticular striation which has been proposed in literature as reliable character. Special attention was paid to the structure of the aleurone grains of the endosperm and the shape of the calcium oxalate crystals in the testa. In contrast to previous assumptions these characters do not allow a certain differentiation either. However, the presence of hexagonal crystals can serve as indicator for samples of I. anisatum. At present a reliable proof of purity of powdered samples of I. verum seems to be possible by chemical analytical methods only. Full article
2340 KiB  
Article
Traditional Mongolian Medicine – A Potential for Drug Discovery
by Christa KLETTER, Sabine GLASL, Theresia THALHAMMER and Samdan NARANTUYA
Sci. Pharm. 2008, 76(1), 49-64; https://doi.org/10.3797/scipharm.0802-04 - 30 Mar 2008
Cited by 23 | Viewed by 2511
Abstract
The principles of Traditional Mongolian Medicine (TMM) and a short history of this medical tradition as practised in the Republic of Mongolia are provided. TMM represents an Asian medical tradition which is greatly influenced by Tibetan Buddhism and which had flourished for centuries [...] Read more.
The principles of Traditional Mongolian Medicine (TMM) and a short history of this medical tradition as practised in the Republic of Mongolia are provided. TMM represents an Asian medical tradition which is greatly influenced by Tibetan Buddhism and which had flourished for centuries in regions inhabited by the Mongols. After the communist ideology had gained recognition in Outer Mongolia in the early 20th century, an introduction of Western medicine and a decline of TMM could be observed. The revival of TMM in the Republic of Mongolia in the second half of the last century led to increasing scientific investigations in this ancient medical system in the country. Joint studies with foreign academic institutions followed. The co-operations of Mongolian academic institutions with Austrian Universities regarding research in traditionally used medicinal plants are discussed and results of joint scientific projects are presented. Full article
230 KiB  
Article
Derivatization with 4-Chloro-7-nitro-2,1,3-benzoxadiazole for the Spectrophotometric and Differential Pulse Polarographic Determination of Acetylcysteine and Captopril
by Rim HAGGAG, Saied BELAL and Rasha SHAALAN
Sci. Pharm. 2008, 76(1), 33-48; https://doi.org/10.3797/scipharm.0711-02 - 30 Mar 2008
Cited by 14 | Viewed by 1325
Abstract
Sensitive methods were developed for the determination of two sulfhydrylcontaining drugs namely acetylcysteine (I) and captopril (II). The methods were based on reacting the drugs with 4-chloro-7-nitro-2,1,3-benzoxadiazole (NBD-Cl) in the presence of sodium tetraborate in absolute methanol. The yellow colored products obtained were [...] Read more.
Sensitive methods were developed for the determination of two sulfhydrylcontaining drugs namely acetylcysteine (I) and captopril (II). The methods were based on reacting the drugs with 4-chloro-7-nitro-2,1,3-benzoxadiazole (NBD-Cl) in the presence of sodium tetraborate in absolute methanol. The yellow colored products obtained were measured spectrophotometrically at 417 and 420 nm for (I) and (II), respectively and by differential pulse polarography at -872 and -1007 mV (vs. Ag/AgCl electrode) for compounds (I) and (II) after getting rid of excess unused reagent by extraction with ether. The different experimental parameters were studied and optimized spectrophotometrically. The proposed methods were validated and applied to the determination of the cited drugs in their pharmaceutical preparations. The results were statistically analyzed and compared to those of a reference HPLC method. Full article
222 KiB  
Article
On the Synthesis and Reactivity of 4-(Oxiran-2-ylmethoxy)cinnoline: Targeting a Cinnoline Analogue of Propranolol
by Wolfgang HOLZER, Gernot A. ELLER and Simeon SCHÖNBERGER
Sci. Pharm. 2008, 76(1), 19-32; https://doi.org/10.3797/scipharm.0802-06 - 30 Mar 2008
Cited by 5 | Viewed by 1209
Abstract
The title compound (2) was prepared by reaction of 4-chlorocinnoline with glycidol/sodium hydride in dry DMF, since treatment of cinnolin-4-ol with epichlorohydrin as well as oxidation of 4-allyloxycinnoline did not succeed. Reaction of 2 with primary and secondary amines leads to aminoalcohols characterized [...] Read more.
The title compound (2) was prepared by reaction of 4-chlorocinnoline with glycidol/sodium hydride in dry DMF, since treatment of cinnolin-4-ol with epichlorohydrin as well as oxidation of 4-allyloxycinnoline did not succeed. Reaction of 2 with primary and secondary amines leads to aminoalcohols characterized by a high tendency to rearrangement and/or elimination. The obtained products were subjected to detailed multinuclear (1H, 13C, 15N) NMR studies. Full article
259 KiB  
Article
The Similarity Principle – New Trends and Applications in Ligand-Based Drug Discovery and ADMET Profiling
by Rita SCHWAHA and Gerhard F. ECKER
Sci. Pharm. 2008, 76(1), 5-18; https://doi.org/10.3797/scipharm.0802-05 - 30 Mar 2008
Cited by 6 | Viewed by 1319
Abstract
Abstract Structural similarity is one of the basic underlying principles in drug discovery and development. Numerous algorithms and concepts are known to search compound libraries for analogous compounds assuming that similar compounds show similar biological activity. In recent years the focus shifted towards [...] Read more.
Abstract Structural similarity is one of the basic underlying principles in drug discovery and development. Numerous algorithms and concepts are known to search compound libraries for analogous compounds assuming that similar compounds show similar biological activity. In recent years the focus shifted towards more complex methods using 3D-shape similarities on one side and highly reductionistic approaches such as smiles substrings on the other side. Furthermore, pharmacological activity profiling becomes increasingly important. Within this review we will highlight selected new concepts and methods applying similarity metrics in the drug discovery and development process. Full article
153 KiB  
Editorial
Editorial
by Wolfgang KUBELKA
Sci. Pharm. 2008, 76(1), 1-4; https://doi.org/10.3797/scipharm.ed-08-01 - 30 Mar 2008
Cited by 1 | Viewed by 858
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