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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).

Sci. Pharm., Volume 74, Issue 1 (March 2006) – 5 articles , Pages 1-75

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469 KiB  
Article
Enhanced Role of Grapefruit Juice on the Anti-schistosomal Activity of Artemether on the Liver of Schistosoma haematobium Infected Hamsters
by Madiha Mahmoud, Fatma Ebeid and Mona Nosseir
Sci. Pharm. 2006, 74(1), 59-75; https://doi.org/10.3797/scipharm.2006.74.59 - 1 Mar 2006
Cited by 2 | Viewed by 1016
Abstract
Artemether (ART) is an efficacious anti-malarial drug that also displays antischistosomal properties. Laboratory studies have found that ART curtails the development of schistosoma worms and thus prevents morbidity. Grapefruit juice was found to interact with various drugs that have been metabolized by a [...] Read more.
Artemether (ART) is an efficacious anti-malarial drug that also displays antischistosomal properties. Laboratory studies have found that ART curtails the development of schistosoma worms and thus prevents morbidity. Grapefruit juice was found to interact with various drugs that have been metabolized by a form of Cytochrome P450, CYP3A4, thus increasing the plasma drug concentration. This work aimed to study the effect of grapefruit juice when administered before infection with Schistosoma haematobium and/or treatment with ART on its anti-schistosomal activity. Golden hamsters were infected each with 300 S. haematobium cercariae and divided into 6 groups (A – F), as follows: Infected control (A); infected received grapefruit juice before infection (B); or received grapefruit juice before infection and treated with ART (200 mg/k) at 5,6 and 7 weeks post infection (WPI) (C); or for 3 successive doses at 12 WPI (D); infected treated with ART alone (200 mg/k) at 5,6 and 7 WPI (E); infected received grapefruit juice (0.5 ml) half an hour before treatment with ART (200 mg/k) at 5,6 and 7 WPI (co-administration) (F). All groups were sacrificed 14 WPI. Some parasitological, biochemical and histopathological estimations were done. Results revealed that, the highest percent of worm reduction was observed in-group F (94.2%) compared to group C,E & D (87.3%, 77.6% & 65.9% respectively). The level of ALT, GGT, urea, thiol, albumin and alkaline phosphatase tend to normalize in accordance with the parasitological results. Neither hepatic granuloma nor prominent histopathological changes could be detected in group F. A minimal number of granulomas (1-3/animal) was observed in group E; meanwhile, the least diameter and collagen content of hepatic S. haematobium granulomas were observed in group C (125.6±5.5 & 2.4±0.572 respectively). The results of the present study demonstrated that, co-administration of grapefruit juice just before treatment with ART at 5, 6& 7 WPI enhanced its anti-schistosomal activity and improved the histopathological changes. Full article
244 KiB  
Article
Identifizierung und Unterscheidung von H2-Antihistaminika und Thioharnstoffderivaten durch Farbreaktionen mit Kupfer(II)-Salzen in stark saurer Lösung
[ Identification and differentiation of H2-antihistamines and thiourea derivatives by colour reaction with Copper(II)-salts in acidic solutions ]
by Lidia Baumann, Kathrin Lutz and Franz Bracher
Sci. Pharm. 2006, 74(1), 53-58; https://doi.org/10.3797/scipharm.2006.74.53 - 1 Mar 2006
Cited by 1 | Viewed by 901
Abstract
Color reactions with Cu(II) salts in strongly acidic solutions are presented for identification of H2-antihistamines and thiourea derivatives. Identification is discussed of Met, cimetidine, ranitidine, famotidine, nizatidine, propylthiouracil, thiopental, thiourea, and tiamulin. Full article
476 KiB  
Article
In-vitro and in-vivo availability of mebeverine hydrochloride suppositories
by Basmah N. Al-Dossary, Omaimah M.N. Al-Gohary and Manal M. El-Khawaas
Sci. Pharm. 2006, 74(1), 31-51; https://doi.org/10.3797/scipharm.2006.74.31 - 1 Mar 2006
Cited by 4 | Viewed by 1174
Abstract
Mebeverine hydrochloride suppositories were prepared using Witepsol H15 suppository base. The effect of different concentrations of various enhancers (surfactants, amino acids and osmotic modifiers) on the drug release form the prepared suppositories was studied. The results showed that mebeverine hydrochloride suppositories containing Brij [...] Read more.
Mebeverine hydrochloride suppositories were prepared using Witepsol H15 suppository base. The effect of different concentrations of various enhancers (surfactants, amino acids and osmotic modifiers) on the drug release form the prepared suppositories was studied. The results showed that mebeverine hydrochloride suppositories containing Brij 35 (2%) and urea (10%) were superior to the other formulations containing the tested enhancers. These formulae showed the highest release rates (K = 0.083 ± 0.004 min-1 and 0.111 ± 0.005 min-1 , respectively) that followed first-order kinetics with t50% of 8.35 ± 0.45 min and 6.24 ± 0.33 min, respectively. Therefore, these two formulae with the control suppositories were subjected to in vivo study in albino rabbits compared to the commercial Duspatalin® tablets and intravenous injection. Higher Cmax (1770.26 ± 165.46 ng.ml-1) within shorter Tmax (0.75 ± 0.20 h) was observed after rectal administration of the control suppositories compared to that of commercially available film-coated tablets (Duspatalin® – 135 mg). A significant difference (p≤0.05) between the absolute bioavailability of Duspatalin® tablets (27.09 ± 3.80%) and control suppositories (46.66 ± 1.72%) was detected. Statistically (p≤0.05), the mean residence time (MRT) after oral administration of Duspatalin® tablets (3.16 ± 0.30 h) was significantly longer than that after the rectal administration of control suppositories (2.73 ± 0.30 h). suppositories containing 2% Brij 35 showed higher plasma levels of the drug (2766.11± 339.50 ng.ml-1) with an absolute bioavailability of 70.50 ± 10.51% compared to 27.09 ± 3.80% for Duspatalin® tablets.
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332 KiB  
Article
Investigation of the Direct Effects of the Alcoholic Extract of Elaeagnus angustifolia L. (Elaeagnaceae) on Dispersed Intestinal Smooth Muscle Cells of Guinea Pig
by Faysal I. Mohammed, Mohammed K. Al-Essa, Yanal A. Shafagoj and Fatma U. Afifi
Sci. Pharm. 2006, 74(1), 21-30; https://doi.org/10.3797/scipharm.2006.74.21 - 1 Mar 2006
Cited by 17 | Viewed by 1417
Abstract
The effect of the ethanolic extract of Elaeagnus angustifolia was tested on dispersed smooth muscle cells (SMC) of the guinea pigs. A slight contractile response was observed when SMC were treated with low concentrations of the extract. Pre-treatment of the SMC with ethanolic [...] Read more.
The effect of the ethanolic extract of Elaeagnus angustifolia was tested on dispersed smooth muscle cells (SMC) of the guinea pigs. A slight contractile response was observed when SMC were treated with low concentrations of the extract. Pre-treatment of the SMC with ethanolic extract of E. angustifolia caused concentration dependent inhibition of acetylcholine-induced contractions of the SMC. Full article
465 KiB  
Article
Synthesis and Anticonvulsant Activity of Certain N-Aralkyl-N-(1-Substituted Cyclohexyl) Benzenamines
by M. Nabil Aboul-Enein, Aida El-Azzouny, Fatma Ragab, Wael Soliman and Yousreya Maklad
Sci. Pharm. 2006, 74(1), 1-19; https://doi.org/10.3797/scipharm.2006.74.1 - 1 Mar 2006
Cited by 7 | Viewed by 1152
Abstract
The synthesis of certain N-aralkyl(1-aminomethylcyclohexyl) benzenamines 6a-i, N-(alkyloxymethyl or aralkyloxymethylcyclohexyl)-N-arylbenzenamines 9a-l and 1-(1-(aralkylphenylamino)cyclohexyl methoxy)-3-isopropylaminopropan-2-ols 11a-c has been accomplished. These compounds exhibited anticonvulsant activity. Compounds 9h, 9b and 11a at doses 0.06, 0.075 and 0.08 mmol/kg, respectively provoked [...] Read more.
The synthesis of certain N-aralkyl(1-aminomethylcyclohexyl) benzenamines 6a-i, N-(alkyloxymethyl or aralkyloxymethylcyclohexyl)-N-arylbenzenamines 9a-l and 1-(1-(aralkylphenylamino)cyclohexyl methoxy)-3-isopropylaminopropan-2-ols 11a-c has been accomplished. These compounds exhibited anticonvulsant activity. Compounds 9h, 9b and 11a at doses 0.06, 0.075 and 0.08 mmol/kg, respectively provoked maximal anticonvulsant potential against pentylenetetrazol (PTZ) induced seizures test compared with diphenylhydantoin (0.2 mmol/kg) and valproic acid (0.24mmol/kg). Full article
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