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Article

Synthesis and Anticonvulsant Activity of Certain N-Aralkyl-N-(1-Substituted Cyclohexyl) Benzenamines

1
Dept. of Pharm. and Med. Chem. (1 Pharm. Chem. Group, 3 Pharmacol. Group) National Research Center, Dokki, Cairo, Egypt
2
Pharmaceutical Chemistry Dept., Faculty of Pharmacy, Cairo University, Cairo, Egypt
3
Dept. of Pharm. and Med. Chem. (1 Pharm. Chem. Group, 3 Pharmacol. Group) National Research Center, Dokki, Cairo, Egypt
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2006, 74(1), 1-19; https://doi.org/10.3797/scipharm.2006.74.1
Submission received: 5 May 2005 / Accepted: 8 November 2005 / Published: 1 March 2006

Abstract

The synthesis of certain N-aralkyl(1-aminomethylcyclohexyl) benzenamines 6a-i, N-(alkyloxymethyl or aralkyloxymethylcyclohexyl)-N-arylbenzenamines 9a-l and 1-(1-(aralkylphenylamino)cyclohexyl methoxy)-3-isopropylaminopropan-2-ols 11a-c has been accomplished. These compounds exhibited anticonvulsant activity. Compounds 9h, 9b and 11a at doses 0.06, 0.075 and 0.08 mmol/kg, respectively provoked maximal anticonvulsant potential against pentylenetetrazol (PTZ) induced seizures test compared with diphenylhydantoin (0.2 mmol/kg) and valproic acid (0.24mmol/kg).
Keywords: N-aralkyl-N-(1-substitutedcyclohexyl)benzenamines; 1-(1-(aralkylphenyl amino)cyclohexylmethoxy)-3-isopropylaminopropan-2-ol; anticonvulsant activity N-aralkyl-N-(1-substitutedcyclohexyl)benzenamines; 1-(1-(aralkylphenyl amino)cyclohexylmethoxy)-3-isopropylaminopropan-2-ol; anticonvulsant activity

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MDPI and ACS Style

Aboul-Enein, M.N.; El-Azzouny, A.; Ragab, F.; Soliman, W.; Maklad, Y. Synthesis and Anticonvulsant Activity of Certain N-Aralkyl-N-(1-Substituted Cyclohexyl) Benzenamines. Sci. Pharm. 2006, 74, 1-19. https://doi.org/10.3797/scipharm.2006.74.1

AMA Style

Aboul-Enein MN, El-Azzouny A, Ragab F, Soliman W, Maklad Y. Synthesis and Anticonvulsant Activity of Certain N-Aralkyl-N-(1-Substituted Cyclohexyl) Benzenamines. Scientia Pharmaceutica. 2006; 74(1):1-19. https://doi.org/10.3797/scipharm.2006.74.1

Chicago/Turabian Style

Aboul-Enein, M. Nabil, Aida El-Azzouny, Fatma Ragab, Wael Soliman, and Yousreya Maklad. 2006. "Synthesis and Anticonvulsant Activity of Certain N-Aralkyl-N-(1-Substituted Cyclohexyl) Benzenamines" Scientia Pharmaceutica 74, no. 1: 1-19. https://doi.org/10.3797/scipharm.2006.74.1

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