Next Article in Journal
Investigation of the Direct Effects of the Alcoholic Extract of Elaeagnus angustifolia L. (Elaeagnaceae) on Dispersed Intestinal Smooth Muscle Cells of Guinea Pig
Previous Article in Journal
Preparation, Quality Control and Biodistribution Studies of two [111In]-Rituximab Immunoconjugates
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Sci. Pharm.
Volume 74
Issue 1
10.3797/scipharm.2006.74.1
scipharm-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Synthesis and Anticonvulsant Activity of Certain N-Aralkyl-N-(1-Substituted Cyclohexyl) Benzenamines

by
M. Nabil Aboul-Enein
1,*,
Aida El-Azzouny
1,
Fatma Ragab
2,
Wael Soliman
1 and
Yousreya Maklad
3
1
Dept. of Pharm. and Med. Chem. (1 Pharm. Chem. Group, 3 Pharmacol. Group) National Research Center, Dokki, Cairo, Egypt
2
Pharmaceutical Chemistry Dept., Faculty of Pharmacy, Cairo University, Cairo, Egypt
3
Dept. of Pharm. and Med. Chem. (1 Pharm. Chem. Group, 3 Pharmacol. Group) National Research Center, Dokki, Cairo, Egypt
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2006, 74(1), 1-19; https://doi.org/10.3797/scipharm.2006.74.1
Submission received: 5 May 2005 / Accepted: 8 November 2005 / Published: 1 March 2006
Versions Notes

Abstract

The synthesis of certain N-aralkyl(1-aminomethylcyclohexyl) benzenamines 6a-i, N-(alkyloxymethyl or aralkyloxymethylcyclohexyl)-N-arylbenzenamines 9a-l and 1-(1-(aralkylphenylamino)cyclohexyl methoxy)-3-isopropylaminopropan-2-ols 11a-c has been accomplished. These compounds exhibited anticonvulsant activity. Compounds 9h, 9b and 11a at doses 0.06, 0.075 and 0.08 mmol/kg, respectively provoked maximal anticonvulsant potential against pentylenetetrazol (PTZ) induced seizures test compared with diphenylhydantoin (0.2 mmol/kg) and valproic acid (0.24mmol/kg).
Keywords: N-aralkyl-N-(1-substitutedcyclohexyl)benzenamines; 1-(1-(aralkylphenyl amino)cyclohexylmethoxy)-3-isopropylaminopropan-2-ol; anticonvulsant activity N-aralkyl-N-(1-substitutedcyclohexyl)benzenamines; 1-(1-(aralkylphenyl amino)cyclohexylmethoxy)-3-isopropylaminopropan-2-ol; anticonvulsant activity

Share and Cite

MDPI and ACS Style

Aboul-Enein, M.N.; El-Azzouny, A.; Ragab, F.; Soliman, W.; Maklad, Y. Synthesis and Anticonvulsant Activity of Certain N-Aralkyl-N-(1-Substituted Cyclohexyl) Benzenamines. Sci. Pharm. 2006, 74, 1-19. https://doi.org/10.3797/scipharm.2006.74.1

AMA Style

Aboul-Enein MN, El-Azzouny A, Ragab F, Soliman W, Maklad Y. Synthesis and Anticonvulsant Activity of Certain N-Aralkyl-N-(1-Substituted Cyclohexyl) Benzenamines. Scientia Pharmaceutica. 2006; 74(1):1-19. https://doi.org/10.3797/scipharm.2006.74.1

Chicago/Turabian Style

Aboul-Enein, M. Nabil, Aida El-Azzouny, Fatma Ragab, Wael Soliman, and Yousreya Maklad. 2006. "Synthesis and Anticonvulsant Activity of Certain N-Aralkyl-N-(1-Substituted Cyclohexyl) Benzenamines" Scientia Pharmaceutica 74, no. 1: 1-19. https://doi.org/10.3797/scipharm.2006.74.1

APA Style

Aboul-Enein, M. N., El-Azzouny, A., Ragab, F., Soliman, W., & Maklad, Y. (2006). Synthesis and Anticonvulsant Activity of Certain N-Aralkyl-N-(1-Substituted Cyclohexyl) Benzenamines. Scientia Pharmaceutica, 74(1), 1-19. https://doi.org/10.3797/scipharm.2006.74.1

Article Metrics

Back to TopTop