Effects Of 2-Methvl-3-propvnvlauinazolin-4-(3H)-one On Vascular Reactivitv In Isolated Porcine Tail Arteries

Odafenkhoa Ojeikere; Cyril Usifoh; Anthony Ebeigbe

doi:10.3797/scipharm.aut-03-27

You are currently viewing a new version of our website. To view the old version click .

Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).

Article

10 November 2003

Effects Of 2-Methvl-3-propvnvlauinazolin-4-(3H)-one On Vascular Reactivitv In Isolated Porcine Tail Arteries

and

Departmenot f Physiology. University of Benin. Benin City, Nigeria

Departmenotf Pharmaceutical Chemistry. University of Benin. Benin City, Nigeria

Author to whom correspondence should be addressed.

Sci. Pharm.2003, 71(4), 321-329;https://doi.org/10.3797/scipharm.aut-03-27

Version Notes

Order Reprints

Abstract

The vascular effects of 2-methyl-3-propynylquinazolin-4-(3H)-one (QUIN) have been studied on isolated porcine tail arteries. QUlN had no effect on resting tension but relaxed, dose-dependently, arteries precontracted with noradrenaline or high-K⁺ in the order: NA > high-K⁺. Also, QUlN inhibited both intracellular (ICD) and extracellular (ECD) Ca²⁺-dependent contractions in the order: ICD > ECD The results suggest that QUlN interferes with vascular Ca²⁺ mobilization.

Keywords:

Quinazolinones; Vascular Reactivity; Smooth muscle

Article Metrics

Citations

Article Access Statistics

Journal Statistics

Multiple requests from the same IP address are counted as one view.

Accessible Charges in Structure-Activity Relationships. A Study on HEPT-based HIV-1 RT Inhibitors

Synthesis and Pharmacological Evaluation of Fenamate Analogues: 1,3,4-Oxadiazol-2-ones and 1,3,4-Oxadiazole-2-thiones