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The Cytokine Profile in Acute Chikungunya Infection is Predictive of Chronic Arthritis 20 Months Post Infection

Department of Medicine, The George Washington University, Washington, DC 20037, USA
Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University, Washington, DC 20037, USA
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA
Army Medical Research Institute for Infectious Diseases, Fort Detrick, MD 21702, USA
Department of Medicine, Allied Research Society LLC, Barranquilla, 080020, Atlántico, Colombia
Grupo de Medicina Comunitaria y Salud Colectiva, Universidad El Bosque, 110121, Bogotá, Colombia
Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
Author to whom correspondence should be addressed.
Diseases 2018, 6(4), 95;
Received: 19 September 2018 / Revised: 15 October 2018 / Accepted: 17 October 2018 / Published: 20 October 2018
(This article belongs to the Special Issue Host-pathogen Interactions in Ebola, Chikungunya, and Zika Viruses)
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The cytokine profile during acute chikungunya infection that predicts future chronic arthritis has not yet been investigated. We conducted a nested case-control study comparing serum cytokine concentrations during acute chikungunya infection in cases (n = 121) that reported the presence of chronic joint pain versus age- and gender-matched controls (n = 121) who reported recovery at 20 months post infection. We observed that a robust cytokine response during acute infection was correlated with a decreased incidence of chronic joint pain and that low TNFα, IL-13, IL-2, and IL-4 during acute infection was predictive of chronic joint pain. These data suggest that a robust cytokine response is necessary for viral clearance and cytokines that are related to immune tolerance during acute infection may be protective for chronic arthritis pathogenesis. View Full-Text
Keywords: arthritis; chikungunya; cytokine; alphavirus arthritis; chikungunya; cytokine; alphavirus

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Chang, A.Y.; Tritsch, S.; Reid, S.P.; Martins, K.; Encinales, L.; Pacheco, N.; Amdur, R.L.; Porras-Ramirez, A.; Rico-Mendoza, A.; Li, G.; Peng, J.; Firestein, G.S.; Simon, G.L.; Bethony, J.M. The Cytokine Profile in Acute Chikungunya Infection is Predictive of Chronic Arthritis 20 Months Post Infection. Diseases 2018, 6, 95.

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