Chronic Hyperplastic Candidiasis—An Adverse Event of Secukinumab in the Oral Cavity: A Case Report and Literature Review
Abstract
1. Introduction
2. Materials and Methods
3. Results—Case Report
4. Results—Literature Review
5. Discussion
Author-Year | A/G | Localisation | Histopathology | Time to Reaction | Time to Resolution | Cessation of SEC | Outcome | Therapy |
---|---|---|---|---|---|---|---|---|
Thompson (2016) [2] | 62/M | Lower lip | Consistent with OLM | 1 week | 6 weeks | Yes | Recovery | 0.1% triamcinolone |
Komori (2017) [24] | 74/F | Left buccal mucosa | Consistent with OLP | 5 months | 2 months | Yes | Recovery | Amphotericin B |
Capusan (2018) [23] | 45/M | Tongue (dorsal/lateral) | Consistent with OLM | 8 months | 2 months | Yes | Recovery | Intralesional corticosteroids, itraconazole |
Benzaquen (2020) [31] | 35/F | Soft palate | Consistent with aphthae | 5 weeks | 3 weeks | No | Recovery | Betamethasone mouthwash |
Daye (2021) [28] | 33/F | Buccal mucosa | Consistent with OLP | 3 months | NR | No | Stabilised | Topical corticosteroid |
Picciani (2021) [30] | 50/F | Tongue (dorsum/lateral) | Consistent with CHC | 2 months | 1 month | Yes | Recovery | Topical miconazole gel |
Farah (2021) [4] | 52/F | Tongue (dorsum) | Consistent with CHC | 6 months | 6 weeks | No | Recovery | Fluconazole a 50 mg |
Pettas (2021) [33] | 22/F | Tongue (dorsum), hard palate | Consistent with CHC and pseudomembranous candidiasis | 1 week | 1 month | No | Recovery | Fluconazole a 100 mg, miconazole gel, CHX 0.2% |
Yogarajah (2022) [29] | 38/M | Tongue (lateral) and buccal mucosa | Consistent with CHC | 6 months | NR | Yes | Recovery | Fluconazole a 100 mg, CHX 0.2% |
Fujita (2023) [27] | 54/M | Lip and buccal mucosa | Consistent with OLP | 1 month | 1 month | Yes | Stabilised | Topical miconazole nitrate, topical corticosteroid, topical tacrolimus |
Glavina (2025) * | 74/M | Tongue (dorsum/lateral) | Consistent with CHC | 3 months | 6 weeks | Yes | Recovery | Fluconazole a 150 mg, nystatin drops |
6. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Abbreviations
ANAs | Antinuclear Antibodies |
AS | Ankylosing Spondylitis |
ATRA | All-Trans Retinoic Acid |
CHC | Chronic Hyperplastic Candidiasis |
CMC | Chronic Mucocutaneous Candidiasis |
COVID-19 | Coronavirus Disease |
cGVHD | Chronic Graft Versus Host Disease |
DIF | Direct Immunofluorescence |
EBER | Epstein–Barr Virus-encoded small RNA |
EBV | Epstein–Barr Virus |
EEM | Erythema Exudativum Multiforme |
ELISA | Enzyme-Linked Immunosorbent Assay |
ENAs | Extractable Nuclear Antigens |
FDA | Food and Drug Administration |
GERD | Gastro-Oesophageal Reflux Disease |
HIV | Human Immunodeficiency Virus |
IBD | Inflammatory Bowel Disease |
IL-17 | Interleukin 17 |
IL-17A | Interleukin 17-A |
IL-23 | Interleukin 23 |
LE | Lupus Erythematosus |
MRONJ | Medication-Related Osteonecrosis of the Jaw |
MS | Multiple Sclerosis |
NHL | Non-Hodgkin Lymphoma |
OLDR | Oral Lichenoid Drug Reaction |
OLP | Oral Lichen Planus |
OLR | Oral Lichenoid Reaction |
OPMD | Oral Potentially Malignant Disorder |
PAS | Periodic Acid-Schiff |
PCI | Percutaneous Coronary Intervention |
PHD | Histopathological Diagnosis |
PRISMA | Preferred Reporting Items for Systematic Reviews and Meta-Analyses |
PsA | Psoriatic Arthritis |
PsO | Psoriasis |
QoL | Quality of Life |
RA | Rheumatoid Arthritis |
SEC | Secukinumab |
TNF-α | Tumour Necrosis Factor-α |
WHO | World Health Organization |
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Glavina, A.; Špiljak, B.; Glavina Durdov, M.; Milić, I.; Perko, M.A.; Mešin Delić, D.; Lugović-Mihić, L. Chronic Hyperplastic Candidiasis—An Adverse Event of Secukinumab in the Oral Cavity: A Case Report and Literature Review. Diseases 2025, 13, 243. https://doi.org/10.3390/diseases13080243
Glavina A, Špiljak B, Glavina Durdov M, Milić I, Perko MA, Mešin Delić D, Lugović-Mihić L. Chronic Hyperplastic Candidiasis—An Adverse Event of Secukinumab in the Oral Cavity: A Case Report and Literature Review. Diseases. 2025; 13(8):243. https://doi.org/10.3390/diseases13080243
Chicago/Turabian StyleGlavina, Ana, Bruno Špiljak, Merica Glavina Durdov, Ivan Milić, Marija Ana Perko, Dora Mešin Delić, and Liborija Lugović-Mihić. 2025. "Chronic Hyperplastic Candidiasis—An Adverse Event of Secukinumab in the Oral Cavity: A Case Report and Literature Review" Diseases 13, no. 8: 243. https://doi.org/10.3390/diseases13080243
APA StyleGlavina, A., Špiljak, B., Glavina Durdov, M., Milić, I., Perko, M. A., Mešin Delić, D., & Lugović-Mihić, L. (2025). Chronic Hyperplastic Candidiasis—An Adverse Event of Secukinumab in the Oral Cavity: A Case Report and Literature Review. Diseases, 13(8), 243. https://doi.org/10.3390/diseases13080243