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Numerical-Sampling-Functionalized Real-Time Index Regulation for Direct k-Domain Calibration in Spectral Domain Optical Coherence Tomography

School of Electronics Engineering, College of IT Engineering, Kyungpook National University, 80, Daehak-ro, Buk-gu, Daegu 41566, Korea
Department of Biomedical Engineering, College of Engineering, Kyungil University, 50, Gamasil-gil, Hayang-eup, Gyeongsan-si, Gyeongsangbuk-do 38428, Korea
Institute of Biomedical Engineering, School of Medicine, Kyungpook National University, 680, Gukchaebosang-ro, Jung-gu, Daegu 41944, Korea
Future IT Innovation Laboratory, Department of Creative IT Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang-si, Gyeongbuk-do 37673, Korea
Department of Nuclear Medicine, Chonnam National University Medical School & Hwasun Hospital, Hwasun 58128, Korea
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Electronics 2018, 7(9), 182;
Received: 9 August 2018 / Revised: 1 September 2018 / Accepted: 7 September 2018 / Published: 9 September 2018
PDF [2830 KB, uploaded 9 September 2018]


An index-regulation technique functionalized by numerical sampling for direct calibration of the non-linear wavenumber (k)-domain to a linear domain in spectral domain optical coherence tomography (SD-OCT) is proposed. The objective of the developed method is to facilitate high-resolution identification of microstructures in biomedical imaging. Subjective optical alignments caused by nonlinear sampling of interferograms in the k-domain tend to hinder depth-dependent signal-to-noise ratios (SNR) and axial resolution in SD-OCT. Moreover, the optical-laser-dependent k-domain requires constant recalibrated in accordance with each laser transition, thereby necessitating either hardware or heavy software compensations. As the key feature of the proposed method, a relatively simple software-based k-domain mask calibration technique was developed to enable real-time linear sampling of k-domain interpolations whilst facilitating image observation through use of an index-regulation technique. Moreover, it has been confirmed that dispersion can be simultaneously compensated with noise residuals generated using the proposed technique, and that use of complex numerical or hardware techniques are no longer required. Observed results, such as fall-off, SNR, and axial resolution clearly exhibit the direct impact of the proposed technique, which could help investigators rapidly achieve optical-laser-independent high-quality SD-OCT images. View Full-Text
Keywords: optical coherence tomography (OCT); Numerical sampling; k-domain; spectral calibration optical coherence tomography (OCT); Numerical sampling; k-domain; spectral calibration

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Han, S.; Kwon, O.; Wijesinghe, R.E.; Kim, P.; Jung, U.; Song, J.; Lee, C.; Jeon, M.; Kim, J. Numerical-Sampling-Functionalized Real-Time Index Regulation for Direct k-Domain Calibration in Spectral Domain Optical Coherence Tomography. Electronics 2018, 7, 182.

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