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Tumor-infiltrating Leukocytes Suppress Local Inflammation Via Interleukin-1 Receptor Antagonist in a Syngeneic Prostate Cancer Model

1
Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11042, Taiwan
2
Department of Pathology, Wan Fang Hospital, Taipei Medical University, Taipei 11042, Taiwan
3
Department of Pathology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11042, Taiwan
4
Department of Hematology and Oncology, Taipei Medical University Hospital and Department of Medicine, Taipei Medical University, Taipei 11042, Taiwan
5
Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11042, Taiwan
*
Author to whom correspondence should be addressed.
Biology 2020, 9(4), 67; https://doi.org/10.3390/biology9040067
Received: 28 February 2020 / Revised: 23 March 2020 / Accepted: 26 March 2020 / Published: 31 March 2020
(This article belongs to the Section Immunology)
Background: Several lines of evidence have demonstrated the tumor-promoting function of inflammation. Since many chemokines are important in coordinating immune cells during inflammation, monitoring intratumoral chemokines provides a way to study the tumor microenvironment. Methods: To identify tumorigenic chemokines, we compared two syngeneic mouse prostate cancer cell lines by an antibody array and quantitative reverse-transcription polymerase chain reaction (RT-PCR). The tumor microenvironment was analyzed by monitoring gene expressions in mouse tumor tissues, primary cells, and tumor-infiltrating leukocytes (TILs). Result: We identified a group of pro-inflammatory chemokines associated with a tumorigenic transgenic adenocarcinoma mouse prostate (TRAMP)-C1 cell line. In the tumor microenvironment, the TILs secrete a natural anti-inflammatory factor, interleukin-1 receptor antagonist (IL1RN), which inhibits the functions of pro-inflammatory molecules and likely accounts for tumor type-specific anti-inflammation functions. Conclusion: Our results support that tumor cells recruit TILs by pro-inflammatory chemokines to establish an IL1RN-mediated anti-inflammatory environment in the syngeneic prostate cancer model. View Full-Text
Keywords: tumor microenvironment; tumor-infiltrating leukocytes; interleukin-1 receptor antagonist tumor microenvironment; tumor-infiltrating leukocytes; interleukin-1 receptor antagonist
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Fan, Y.-C.; Chen, W.-Y.; Lee, K.-D.; Tsai, Y.-C. Tumor-infiltrating Leukocytes Suppress Local Inflammation Via Interleukin-1 Receptor Antagonist in a Syngeneic Prostate Cancer Model. Biology 2020, 9, 67.

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