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Correction to Biology 2025, 14(6), 604.
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Correction

Correction: Morgan et al. Precision Medicine: IL-1RA and Pancreatic Cancer Organoids. Biology 2025, 14, 604

by
Annah G. Morgan
1,
Michelle F. Griffin
1,2,
Michael T. Longaker
1,2 and
Jeffrey A. Norton
1,3,*
1
Hagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA
2
Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA
3
Division of General Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA
*
Author to whom correspondence should be addressed.
Biology 2025, 14(9), 1133; https://doi.org/10.3390/biology14091133
Submission received: 14 August 2025 / Accepted: 22 August 2025 / Published: 27 August 2025
(This article belongs to the Section Cancer Biology)
Browse Figures
Versions Notes

1. Error in Figure/Table

In the original publication [1], there were mistakes in Figures 4 and 8 as published.

1.1. Figure 4

In the original publication, there was a mistake in Figure 4 as published. The incorrect image for ‘αSMA, IL-1RA treated’ was included due to unclear labeling of the image file. The corrected Figure 4 appears below.

1.2. Figure 8

In the original publication, there was a mistake in Figure 8 as published. The incorrect image for ‘CD8, IL-1RA treated’ was included due to unclear labeling of the image file. The corrected Figure 8 appears below.
The authors state that the scientific conclusions are unaffected.
This correction was approved by the Academic Editor. The original publication has also been updated.

Reference

  1. Morgan, A.G.; Griffin, M.F.; Longaker, M.T.; Norton, J.A. Precision Medicine: IL-1RA and Pancreatic Cancer Organoids. Biology 2025, 14, 604. [Google Scholar] [CrossRef]
Biology 14 01133 g001
Figure 4. Immunofluorescence staining of murine pancreatic ductal adenocarcinoma (PDAC) organoids harvested on day 14. The tumor organoids were either untreated control (bottom row) or treated with IL-1RA (top row). IL-1RA treatment significantly decreased expression of alpha-smooth muscle actin (α-SMA) (p < 0.05), and significantly increased the expression of CD4+ (p < 0.05) and CD8+ (p < 0.05) immune cells. The single asterisk (*) indicates that the p value is less than or equal to 0.05, but greater than 0.01.
Figure 4. Immunofluorescence staining of murine pancreatic ductal adenocarcinoma (PDAC) organoids harvested on day 14. The tumor organoids were either untreated control (bottom row) or treated with IL-1RA (top row). IL-1RA treatment significantly decreased expression of alpha-smooth muscle actin (α-SMA) (p < 0.05), and significantly increased the expression of CD4+ (p < 0.05) and CD8+ (p < 0.05) immune cells. The single asterisk (*) indicates that the p value is less than or equal to 0.05, but greater than 0.01.
Biology 14 01133 g001
Biology 14 01133 g002
Figure 8. Immunofluorescence staining of human pancreatic ductal adenocarcinoma (PDAC) organoids harvested on day 14. The tumor organoids were either untreated control (bottom row) or treated with IL-1 receptor antagonist (IL-1RA) (top row). There was significantly increased expression of CD4 (p < 0.05) and CD8 (p < 0.05) immune cell markers following treatment. The single asterisk (*) indicates that the p value is less than or equal to 0.05, but greater than 0.01. Major histocompatibility complex II (MHCII), a macrophage and antigen-presenting CAF (apCAF) marker, is significantly increased with IL-1RA treatment (p < 0.001). Three asterisks (***) indicate that the p value is less than or equal to 0.001, but greater than 0.0001. IL-1RA treatment significantly decreases C-X-C motif chemokine ligand 12 (CXCL12), a marker of immunomodulatory CAFs (iCAFs) (p < 0.01). Two asterisks (**) indicate that the p value is less than or equal to 0.01, but greater than 0.001.
Figure 8. Immunofluorescence staining of human pancreatic ductal adenocarcinoma (PDAC) organoids harvested on day 14. The tumor organoids were either untreated control (bottom row) or treated with IL-1 receptor antagonist (IL-1RA) (top row). There was significantly increased expression of CD4 (p < 0.05) and CD8 (p < 0.05) immune cell markers following treatment. The single asterisk (*) indicates that the p value is less than or equal to 0.05, but greater than 0.01. Major histocompatibility complex II (MHCII), a macrophage and antigen-presenting CAF (apCAF) marker, is significantly increased with IL-1RA treatment (p < 0.001). Three asterisks (***) indicate that the p value is less than or equal to 0.001, but greater than 0.0001. IL-1RA treatment significantly decreases C-X-C motif chemokine ligand 12 (CXCL12), a marker of immunomodulatory CAFs (iCAFs) (p < 0.01). Two asterisks (**) indicate that the p value is less than or equal to 0.01, but greater than 0.001.
Biology 14 01133 g002
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MDPI and ACS Style

Morgan, A.G.; Griffin, M.F.; Longaker, M.T.; Norton, J.A. Correction: Morgan et al. Precision Medicine: IL-1RA and Pancreatic Cancer Organoids. Biology 2025, 14, 604. Biology 2025, 14, 1133. https://doi.org/10.3390/biology14091133

AMA Style

Morgan AG, Griffin MF, Longaker MT, Norton JA. Correction: Morgan et al. Precision Medicine: IL-1RA and Pancreatic Cancer Organoids. Biology 2025, 14, 604. Biology. 2025; 14(9):1133. https://doi.org/10.3390/biology14091133

Chicago/Turabian Style

Morgan, Annah G., Michelle F. Griffin, Michael T. Longaker, and Jeffrey A. Norton. 2025. "Correction: Morgan et al. Precision Medicine: IL-1RA and Pancreatic Cancer Organoids. Biology 2025, 14, 604" Biology 14, no. 9: 1133. https://doi.org/10.3390/biology14091133

APA Style

Morgan, A. G., Griffin, M. F., Longaker, M. T., & Norton, J. A. (2025). Correction: Morgan et al. Precision Medicine: IL-1RA and Pancreatic Cancer Organoids. Biology 2025, 14, 604. Biology, 14(9), 1133. https://doi.org/10.3390/biology14091133

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