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16 November 2025

Genome-Wide Identification and Expression Analysis of the PEPC Gene Family in Zanthoxylum armatum Reveals Potential Roles in Environmental Adaptation

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1
Chongqing Key Laboratory of Economic Plant Biotechnology, Collaborative Innovation Center of Special Plant Industry in Chongqing, College of Smart Agriculture, Chongqing University of Arts and Sciences, Chongqing 402160, China
2
Chongqing Key Laboratory of Forest Ecological Restoration and Utilization in the Three Gorges Reservoir Area, Chongqing Academy of Forestry Sciences, Chongqing 400036, China
3
Hubei Key Laboratory of Spices & Horticultural Plant Germplasm Innovation & Utilization, Yangtze University, Jingzhou 434023, China
4
Chongqing Agricultural Technology Promotion General Station, Chongqing 401120, China
Biology2025, 14(11), 1605;https://doi.org/10.3390/biology14111605 
(registering DOI)
This article belongs to the Section Genetics and Genomics

Simple Summary

This study presents the first comprehensive analysis of the PEPC (Phosphoenolpyruvate carboxylase) gene family in the Sichuan pepper plant (Zanthoxylum armatum). PEPC, a key enzyme in photosynthetic carbon fixation and stress response, was investigated using integrated bioinformatics and molecular approaches. Twelve PEPC genes were identified, exhibiting distinct expression patterns across environmental gradients. Notably, the highest expression levels were observed in high-altitude, high-light regions of Yunnan, China. This finding indicate that these genes may help Z. armatum adapt to diverse climates and resist stresses such as drought. This finding provides genetic resources and a theoretical basis for improving photosynthetic efficiency, stress response, and fruit quality in Z. armatum, offering important value for promoting the breeding and sustainable development of this economically significant crop.

Abstract

Phosphoenolpyruvate carboxylase (PEPC) is a crucial enzyme in plant photosynthesis and stress responses, yet its gene family remained uncharacterized in Zanthoxylum armatum. This study presents the first genome-wide identification and comprehensive analysis of the PEPC gene family in Z. armatum. A total of 12 ZaPEPC genes were identified and classified into plant-type (PTPC) and bacterial-type (BTPC) subfamilies based on phylogenetic analysis. These genes exhibited conserved protein domains but distinct gene structures, with evidence of gene duplication events contributing to family expansion. Promoter analysis revealed an abundance of stress- and hormone-responsive cis-elements, particularly those related to light, abscisic acid (ABA), and methyl jasmonate (MeJA). Expression profiling demonstrated that ZaPEPC genes display environment-specific expression patterns, with ZaPEPC7 and ZaPEPC11 showing significantly higher expression in high-altitude, high-light environments (Yunnan) compared to other regions (Shandong and Chongqing). Co-expression network analysis further indicated interactions between specific ZaPEPCs and stress-related transcription factors. These findings systematically reveal the molecular characteristics and potential roles of the ZaPEPC gene family in environmental adaptation, providing valuable genetic resources and a theoretical foundation for improving stress tolerance and photosynthetic efficiency in Z. armatum through molecular breeding.

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