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Article

Interaction of Particles with Langmuir Monolayers of 1,2-Dipalmitoyl-Sn-Glycero-3-Phosphocholine: A Matter of Chemistry?

1
Departamento de Química Física, Universidad Complutense de Madrid, 28040 Madrid, Spain
2
Instituto Pluridisciplinar, Universidad Complutense de Madrid, 28040 Madrid, Spain
3
Istituto di Chimica della Materia Condensata e di Tecnologia per l’Energia (ICMATE)-U.O.S. Genova, Consiglio Nazionale delle Ricerche (CNR), 16149 Genova, Italy
*
Authors to whom correspondence should be addressed.
Coatings 2020, 10(5), 469; https://doi.org/10.3390/coatings10050469
Received: 22 March 2020 / Revised: 11 April 2020 / Accepted: 7 May 2020 / Published: 10 May 2020
(This article belongs to the Special Issue Fluid Interfaces)
Lipid layers are considered among the first protective barriers of the human body against pollutants, e.g., skin, lung surfactant, or tear film. This makes it necessary to explore the physico-chemical bases underlying the interaction of pollutants and lipid layers. This work evaluates using a pool of surface-sensitive techniques, the impact of carbon black and fumed silica particles on the behavior of Langmuir monolayers of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC). The results show that the incorporation of particles into the lipid monolayers affects the surface pressure–area isotherm of the DPPC, modifying both the phase behavior and the collapse conditions. This is explained considering that particles occupy a part of the area available for lipid organization, which affects the lateral organization of the lipid molecules, and consequently the cohesion interactions within the monolayer. Furthermore, particles incorporation worsens the mechanical performance of lipid layers, which may impact negatively in different processes presenting biological relevance. The modification induced by the particles has been found to be dependent on their specific chemical nature. This work tries to shed light on some of the most fundamental physico-chemical bases governing the interaction of pollutants with lipid layers, which plays an essential role on the design of strategies for preventing the potential health hazards associated with pollution. View Full-Text
Keywords: lipids; pollutants; Langmuir monolayers; particles; rheology lipids; pollutants; Langmuir monolayers; particles; rheology
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MDPI and ACS Style

Guzmán, E.; Santini, E.; Ferrari, M.; Liggieri, L.; Ravera, F. Interaction of Particles with Langmuir Monolayers of 1,2-Dipalmitoyl-Sn-Glycero-3-Phosphocholine: A Matter of Chemistry? Coatings 2020, 10, 469. https://doi.org/10.3390/coatings10050469

AMA Style

Guzmán E, Santini E, Ferrari M, Liggieri L, Ravera F. Interaction of Particles with Langmuir Monolayers of 1,2-Dipalmitoyl-Sn-Glycero-3-Phosphocholine: A Matter of Chemistry? Coatings. 2020; 10(5):469. https://doi.org/10.3390/coatings10050469

Chicago/Turabian Style

Guzmán, Eduardo, Eva Santini, Michele Ferrari, Libero Liggieri, and Francesca Ravera. 2020. "Interaction of Particles with Langmuir Monolayers of 1,2-Dipalmitoyl-Sn-Glycero-3-Phosphocholine: A Matter of Chemistry?" Coatings 10, no. 5: 469. https://doi.org/10.3390/coatings10050469

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