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Article

Biocompatibility and Comfort during Extended Wear of Mel4 Peptide-Coated Antimicrobial Contact Lenses

1
School of Optometry and Vision Science, UNSW Sydney, Sydney, NSW 2041, Australia
2
School of Optometry, Aston University, Birmingham B4 7ET, UK
3
School of Medical Sciences, University of Hyderabad, Hyderabad 500 046, India
4
Bausch & Lomb Contact Lens Centre, L V Prasad Eye Institute, Hyderabad 500 034, India
5
The Cornea Institute, L V Prasad Eye Institute, Hyderabad 500 034, India
6
Jhaveri Microbiology Centre, L V Prasad Eye Institute, Hyderabad 500 034, India
*
Author to whom correspondence should be addressed.
Academic Editor: Andreana Marino
Antibiotics 2022, 11(1), 58; https://doi.org/10.3390/antibiotics11010058
Received: 3 December 2021 / Revised: 30 December 2021 / Accepted: 31 December 2021 / Published: 3 January 2022
(This article belongs to the Special Issue Ocular Surface Infection and Antimicrobials)
(1) Purpose: This study aimed to investigate the effects of Mel4 antimicrobial contact lenses (MACL) on the ocular surface and comfort during extended wear. (2) Methods: A prospective, randomised, double-masked, contralateral clinical trial was conducted with 176 subjects to evaluate the biocompatibility of contralateral wear of MACL. The wearing modality was 14-day extended lens wear for three months. The participants were assessed at lens dispensing, after one night, two weeks, one month and three months of extended wear and one month after study completion. (3) Results: There were no significant differences (p > 0.05) in ocular redness or palpebral roughness between Mel4 and control eyes at any of the study visits. There was no significant difference (p > 0.05) in corneal staining between Mel4 and control eyes. There were no significant differences in front surface wettability or deposits or back surface debris (p > 0.05). No statistically significant differences (p > 0.05) were found in comfort, dryness, CLDEQ-8 scores lens or edge awareness. There was no evidence for delayed reactions on the ocular surface after cessation of lens wear. (4) Conclusion: The novel MACLs showed similar comfort to control lenses and were biocompatible during extended wear. Thus, these lenses were compatible with the ocular surface. View Full-Text
Keywords: Mel4 peptide; antimicrobial contact lens; extended wear; biocompatibility; comfort; clinical trail Mel4 peptide; antimicrobial contact lens; extended wear; biocompatibility; comfort; clinical trail
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MDPI and ACS Style

Kalaiselvan, P.; Dutta, D.; Konda, N.; Vaddavalli, P.K.; Sharma, S.; Stapleton, F.; Willcox, M.D.P. Biocompatibility and Comfort during Extended Wear of Mel4 Peptide-Coated Antimicrobial Contact Lenses. Antibiotics 2022, 11, 58. https://doi.org/10.3390/antibiotics11010058

AMA Style

Kalaiselvan P, Dutta D, Konda N, Vaddavalli PK, Sharma S, Stapleton F, Willcox MDP. Biocompatibility and Comfort during Extended Wear of Mel4 Peptide-Coated Antimicrobial Contact Lenses. Antibiotics. 2022; 11(1):58. https://doi.org/10.3390/antibiotics11010058

Chicago/Turabian Style

Kalaiselvan, Parthasarathi, Debarun Dutta, Nagaraju Konda, Pravin K. Vaddavalli, Savitri Sharma, Fiona Stapleton, and Mark D.P. Willcox. 2022. "Biocompatibility and Comfort during Extended Wear of Mel4 Peptide-Coated Antimicrobial Contact Lenses" Antibiotics 11, no. 1: 58. https://doi.org/10.3390/antibiotics11010058

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