Next Article in Journal
CRISPR/Cas12a-Based Ultrasensitive and Rapid Detection of JAK2 V617F Somatic Mutation in Myeloproliferative Neoplasms
Next Article in Special Issue
State of the Art on the SARS-CoV-2 Toolkit for Antigen Detection: One Year Later
Previous Article in Journal
Wearable Biosensors for Non-Invasive Sweat Diagnostics
Previous Article in Special Issue
Impedimetric and Plasmonic Sensing of Collagen I Using a Half-Antibody-Supported, Au-Modified, Self-Assembled Monolayer System
Review

The Role of Peptides in the Design of Electrochemical Biosensors for Clinical Diagnostics

1
Department of Chemistry “Ugo Schiff”, University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino, Italy
2
Department of Molecular Sciences and Nanosystems, Ca’ Foscari University of Venice, Via Torino 155, 30172 Venice, Italy
*
Author to whom correspondence should be addressed.
Biosensors 2021, 11(8), 246; https://doi.org/10.3390/bios11080246
Received: 31 May 2021 / Revised: 10 July 2021 / Accepted: 19 July 2021 / Published: 23 July 2021
Peptides represent a promising class of biorecognition elements that can be coupled to electrochemical transducers. The benefits lie mainly in their stability and selectivity toward a target analyte. Furthermore, they can be synthesized rather easily and modified with specific functional groups, thus making them suitable for the development of novel architectures for biosensing platforms, as well as alternative labelling tools. Peptides have also been proposed as antibiofouling agents. Indeed, biofouling caused by the accumulation of biomolecules on electrode surfaces is one of the major issues and challenges to be addressed in the practical application of electrochemical biosensors. In this review, we summarise trends from the last three years in the design and development of electrochemical biosensors using synthetic peptides. The different roles of peptides in the design of electrochemical biosensors are described. The main procedures of selection and synthesis are discussed. Selected applications in clinical diagnostics are also described. View Full-Text
Keywords: peptide; electrochemical biosensor; antifouling; protease; biomarker; bioreceptor peptide; electrochemical biosensor; antifouling; protease; biomarker; bioreceptor
Show Figures

Figure 1

MDPI and ACS Style

Sfragano, P.S.; Moro, G.; Polo, F.; Palchetti, I. The Role of Peptides in the Design of Electrochemical Biosensors for Clinical Diagnostics. Biosensors 2021, 11, 246. https://doi.org/10.3390/bios11080246

AMA Style

Sfragano PS, Moro G, Polo F, Palchetti I. The Role of Peptides in the Design of Electrochemical Biosensors for Clinical Diagnostics. Biosensors. 2021; 11(8):246. https://doi.org/10.3390/bios11080246

Chicago/Turabian Style

Sfragano, Patrick S., Giulia Moro, Federico Polo, and Ilaria Palchetti. 2021. "The Role of Peptides in the Design of Electrochemical Biosensors for Clinical Diagnostics" Biosensors 11, no. 8: 246. https://doi.org/10.3390/bios11080246

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop