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Open AccessArticle

Dopamine and Striatal Neuron Firing Respond to Frequency-Dependent DBS Detected by Microelectrode Arrays in the Rat Model of Parkinson’s Disease

by 1,2, 1,2, 1,2, 1,2, 1,2, 1,2, 1,2, 1,2, 1,2 and 1,2,*
1
State Key Laboratory of Transducer Technology, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing 100190, China
2
University of Chinese Academy of Sciences, Beijing 100049, China
*
Author to whom correspondence should be addressed.
Biosensors 2020, 10(10), 136; https://doi.org/10.3390/bios10100136
Received: 24 August 2020 / Revised: 15 September 2020 / Accepted: 21 September 2020 / Published: 28 September 2020
(1) Background: Deep brain stimulation (DBS) is considered as an efficient treatment method for alleviating motor symptoms in Parkinson’s disease (PD), while different stimulation frequency effects on the specific neuron patterns at the cellular level remain unknown. (2) Methods: In this work, nanocomposites-modified implantable microelectrode arrays (MEAs) were fabricated to synchronously record changes of dopamine (DA) concentration and striatal neuron firing in the striatum during subthalamic nucleus DBS, and different responses of medium spiny projecting neurons (MSNs) and fast spiking interneurons (FSIs) to DBS were analyzed. (3) Results: DA concentration and striatal neuron spike firing rate showed a similar change as DBS frequency changed from 10 to 350 Hz. Note that the increases in DA concentration (3.11 ± 0.67 μM) and neural spike firing rate (15.24 ± 2.71 Hz) were maximal after the stimulation at 100 Hz. The MSNs firing response to DBS was significant, especially at 100 Hz, while the FSIs remained stable after various stimulations. (4) Conclusions: DBS shows the greatest regulatory effect on DA concentration and MSNs firing rate at 100 Hz stimulation. This implantable MEA in the recording of the neurotransmitter and neural spike pattern response to DBS provides a new insight to understand the mechanism of PD at the cellular level. View Full-Text
Keywords: MEA; DBS; frequency-dependent; dopamine; MSNs MEA; DBS; frequency-dependent; dopamine; MSNs
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MDPI and ACS Style

Xiao, G.; Song, Y.; Zhang, Y.; Xing, Y.; Xu, S.; Wang, M.; Wang, J.; Chen, D.; Chen, J.; Cai, X. Dopamine and Striatal Neuron Firing Respond to Frequency-Dependent DBS Detected by Microelectrode Arrays in the Rat Model of Parkinson’s Disease. Biosensors 2020, 10, 136. https://doi.org/10.3390/bios10100136

AMA Style

Xiao G, Song Y, Zhang Y, Xing Y, Xu S, Wang M, Wang J, Chen D, Chen J, Cai X. Dopamine and Striatal Neuron Firing Respond to Frequency-Dependent DBS Detected by Microelectrode Arrays in the Rat Model of Parkinson’s Disease. Biosensors. 2020; 10(10):136. https://doi.org/10.3390/bios10100136

Chicago/Turabian Style

Xiao, Guihua; Song, Yilin; Zhang, Yu; Xing, Yu; Xu, Shengwei; Wang, Mixia; Wang, Junbo; Chen, Deyong; Chen, Jian; Cai, Xinxia. 2020. "Dopamine and Striatal Neuron Firing Respond to Frequency-Dependent DBS Detected by Microelectrode Arrays in the Rat Model of Parkinson’s Disease" Biosensors 10, no. 10: 136. https://doi.org/10.3390/bios10100136

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