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Open AccessArticle

High-Performance Sample Substrate of Gold Nanoparticle Multilayers for Surface-Assisted Laser Desorption/Ionization Mass Spectrometry

1
Graduate Institute of Nanomedicine and Medical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 11031, Taiwan
2
Division of Oral Pathology, Department of Dentistry, Taipei Medical University Hospital, Taipei 11031, Taiwan
3
School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan
4
Department of Chemistry, Tunghai University, Taichung 40704, Taiwan
5
International Ph.D. Program in Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 11031, Taiwan
6
Research Center of Biomedical Device, Taipei Medical University, Taipei 11031, Taiwan
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Nanomaterials 2019, 9(8), 1078; https://doi.org/10.3390/nano9081078
Received: 4 July 2019 / Revised: 21 July 2019 / Accepted: 23 July 2019 / Published: 27 July 2019
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Abstract

The development of a sample substrate with superior performance for desorption and ionization of analyte is the key issue to ameliorate the quality of mass spectra for measurements of small molecules in surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS). Herein, the homogeneous sample substrate of gold nanoparticle multilayers (AuNPs-ML) with hexagonal lattice was successfully prepared by self-assembly technique. With strong surface plasmon resonance absorption and superior photothermal effect, the sample substrate of AuNPs-ML exhibited high signal sensitivity and low background noise for the detection of model analyte of glucose without additional matrixes in SALDI-MS. Furthermore, compared to merchant matrixes of α-cyano-4-hydroxycinnamic acid (CHCA) and 2,5-dihydroxybenzoic acid (DHB), the sample substrate of AuNPs-ML was demonstrated to ameliorate the quality of mass spectra, including signal strength, background interference and signal/noise (S/N) ratio. The sucrose and tryptophan were also measured to show the extensive applications of AuNPs-ML sample substrate for the detections of small molecules in SALDI-MS. Most importantly, the remarkable reproducibility of glucose mass spectra with relative signal of 7.3% was obtained by the use of AuNPs-ML sample substrate for SALDI-MS. The homogeneous sample substrate of AuNPs-ML greatly improved the quality of mass spectra because of its strong absorption of laser energy, low specific heat, high heat conductivity and extraordinary homogeneity. We believe that AuNPs-ML could be a practical sample substrate for small molecule detection in SALDI-MS. View Full-Text
Keywords: gold nanoparticles; self-assembly; gold nanoparticle multilayers; sample substrate; photothermal effect; reproducibility gold nanoparticles; self-assembly; gold nanoparticle multilayers; sample substrate; photothermal effect; reproducibility
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Liu, Y.-C.; Chang, Y.-H.; Lin, Y.-H.; Liou, C.-C.; Kuo, T.-R. High-Performance Sample Substrate of Gold Nanoparticle Multilayers for Surface-Assisted Laser Desorption/Ionization Mass Spectrometry. Nanomaterials 2019, 9, 1078.

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