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Biomimetic Collagen/Zn2+-Substituted Calcium Phosphate Composite Coatings on Titanium Substrates as Prospective Bioactive Layer for Implants: A Comparative Study Spin Coating vs. MAPLE

1
Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Polizu Street No.1, 011061 Bucharest, Romania
2
National Institute for Laser, Plasma and Radiation Physics, Atomiştilor Street No. 409, 077125 Măgurele, Romania
3
Stefan S. Nicolau’ Institute of Virology, Romanian Academy, 011061 Bucharest, Romania
4
Academy of Romanian Scientists, Splaiul Independentei Street No. 54, 011061 Bucharest, Romania
*
Author to whom correspondence should be addressed.
Nanomaterials 2019, 9(5), 692; https://doi.org/10.3390/nano9050692
Received: 8 April 2019 / Revised: 22 April 2019 / Accepted: 26 April 2019 / Published: 3 May 2019
(This article belongs to the Special Issue Synthesis and Modification of Nanostructured Thin Films)
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Abstract

Synthesis of biomimetic materials for implants and prostheses is a hot topic in nanobiotechnology strategies. Today the major approach of orthopaedic implants in hard tissue engineering is represented by titanium implants. A comparative study of hybrid thin coatings deposition was performed by spin coating and matrix-assisted pulsed laser evaporation (MAPLE) onto titanium substrates. The Collagen-calcium phosphate (Coll-CaPs) combination was selected as the best option to mimic natural bone tissue. To accelerate the mineralization process, Zn2+ ions were inserted by substitution in CaPs. A superior thin film homogeneity was assessed by MAPLE, as shown by scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) microscopy. A decrease of P-O and amide absorbance bands was observed as a consequence of different Zn2+ amounts. A variety of structural modifications of the apatite layer are then generated, which influenced the confinement process towards the collagen template. The in-vitro Simulated Body Fluid (SBF) assay demonstrated the ability of Coll/Zn2+-CaPs coatings to stimulate the mineralization process as a result of synergic effects in the collagen-Zn2+ substituted apatite. For both deposition methods, the formation of droplets associated to the growth of CaPs particulates inside the collagen matrix was visualized. This supports the prospective behavior of MAPLE biomimetic coatings to induce mineralization, as an essential step of fast implant integration with vivid tissues. View Full-Text
Keywords: Zn2+ substituted Coll-CaPs biomimetic layers; MAPLE; spin coating Zn2+ substituted Coll-CaPs biomimetic layers; MAPLE; spin coating
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Neacsu, I.A.; Arsenie, L.V.; Trusca, R.; Ardelean, I.L.; Mihailescu, N.; Mihailescu, I.N.; Ristoscu, C.; Bleotu, C.; Ficai, A.; Andronescu, E. Biomimetic Collagen/Zn2+-Substituted Calcium Phosphate Composite Coatings on Titanium Substrates as Prospective Bioactive Layer for Implants: A Comparative Study Spin Coating vs. MAPLE. Nanomaterials 2019, 9, 692.

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