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Nanomaterials 2019, 9(4), 551; https://doi.org/10.3390/nano9040551

Remote Magnetic Control of Autophagy in Mouse B-Lymphoma Cells with Iron Oxide Nanoparticles

1
Institute of Biomedical Engineering, College of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu 30010, Taiwan
2
Department of Electrical and Computer Engineering, College of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu 30010, Taiwan
3
Gynecologic Oncology Section Department of Obstetrics and Gynecology, Hsinchu MacKay Memorial Hospital, Hsinchu 300, Taiwan
4
Department of Biological Science and Technology, National Chiao Tung University, Hsinchu 30010, Taiwan
5
Division of Allergy, Immunology and Rheumatology, MacKay Memorial Hospital, Taipei 10491, Taiwan
*
Author to whom correspondence should be addressed.
These three authors contributed equally to this work.
Received: 8 March 2019 / Revised: 24 March 2019 / Accepted: 26 March 2019 / Published: 4 April 2019
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Abstract

Autophagy is the spontaneous degradation of intracellular proteins and organelles in response to nutrient deprivation. The phagocytosis of iron oxide nanoparticles (IONPs) results in intracellular degradation that can be exploited for use in cancer treatment. Non-invasive magnetic control has emerged as an important technology, with breakthroughs achieved in areas such as magneto-thermal therapy and drug delivery. This study aimed to regulate autophagy in mouse B-lymphoma cells (A20) through the incorporation of IONPs–quantum dots (QDs). We hypothesized that with the application of an external magnetic field after phagocytosis of IONPs–QDs, autophagy of intracellular IONPs–QDs could be regulated in a non-invasive manner and subsequently modulate the regulation of inflammatory responses. The potential of this approach as a cancer treatment method was explored. The application of IONPs and an external magnetic force enabled the non-invasive regulation of cell autophagy and modulation of the self-regulatory function of cells. The combination of non-invasive magnetic fields and nanotechnology could provide a new approach to cancer treatment. View Full-Text
Keywords: autophagy; magnetic field; iron oxide nanoparticle; proinflammatory cytokine autophagy; magnetic field; iron oxide nanoparticle; proinflammatory cytokine
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Lin, Y.-R.; Chan, C.-H.; Lee, H.-T.; Cheng, S.-J.; Yang, J.-W.; Chang, S.-J.; Lin, S.-F.; Chen, G.-Y. Remote Magnetic Control of Autophagy in Mouse B-Lymphoma Cells with Iron Oxide Nanoparticles. Nanomaterials 2019, 9, 551.

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