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Nanomaterials 2019, 9(4), 547;

Biodegradable Redox-Sensitive Star Polymer Nanomicelles for Enhancing Doxorubicin Delivery

School of Chemical Engineering & Light Industry, Guangdong University of Technology, Guangzhou 510006, China
Department of Materials Science and Engineering, National Taiwan University of Science and Technology, No. 43, Sec. 4, Keelung Road, Taipei 106, Taiwan
Authors to whom correspondence should be addressed.
Received: 19 March 2019 / Revised: 30 March 2019 / Accepted: 1 April 2019 / Published: 4 April 2019
PDF [3116 KB, uploaded 4 April 2019]


A typical amphiphilic star polymer adamantane-[poly(lactic-co-glycolic acid)-bis(2-carboxyethyl) sulfide-poly(ethylene glycol) monomethyl ether)]4 with a specific hydrophilic/redox-sensitive/hydrophobic structure was designed and synthesized through ring opening and esterification reactions. The self-assembled nanomicelles were used as doxorubicin (DOX) delivery vehicles with suitable critical micelle concentrations (5.0 mg/L). After the drug being loaded, drug-loaded micelles showed good drug-loading efficiency (10.39%), encapsulation efficiency (58.1%), and drug release (up to 60%) under simulated biological environment conditions. In addition, the backbone structure of the biodegradable polymer was easily hydrolyzed by the action of biological enzymes. As expected, cell-based studies showed that the designed polymer micelles possessed good biocompatibility (a survival rate of 85% for NH-3T3 cells). Moreover, the drug (DOX) still maintained good anti-cancer effects after being loaded, which caused 40% of MCF-7 cells to survive. These redox-sensitive micelles showed anti-tumor therapeutic potential. View Full-Text
Keywords: adamantane; star; redox-sensitive; nanomicelles; biodegradable polymer adamantane; star; redox-sensitive; nanomicelles; biodegradable polymer

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Li, M.; Guo, J.-W.; Wen, W.-Q.; Chen, J.-K. Biodegradable Redox-Sensitive Star Polymer Nanomicelles for Enhancing Doxorubicin Delivery. Nanomaterials 2019, 9, 547.

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