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Nanomaterials 2019, 9(4), 547; https://doi.org/10.3390/nano9040547

Biodegradable Redox-Sensitive Star Polymer Nanomicelles for Enhancing Doxorubicin Delivery

1
School of Chemical Engineering & Light Industry, Guangdong University of Technology, Guangzhou 510006, China
2
Department of Materials Science and Engineering, National Taiwan University of Science and Technology, No. 43, Sec. 4, Keelung Road, Taipei 106, Taiwan
*
Authors to whom correspondence should be addressed.
Received: 19 March 2019 / Revised: 30 March 2019 / Accepted: 1 April 2019 / Published: 4 April 2019
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Abstract

A typical amphiphilic star polymer adamantane-[poly(lactic-co-glycolic acid)-bis(2-carboxyethyl) sulfide-poly(ethylene glycol) monomethyl ether)]4 with a specific hydrophilic/redox-sensitive/hydrophobic structure was designed and synthesized through ring opening and esterification reactions. The self-assembled nanomicelles were used as doxorubicin (DOX) delivery vehicles with suitable critical micelle concentrations (5.0 mg/L). After the drug being loaded, drug-loaded micelles showed good drug-loading efficiency (10.39%), encapsulation efficiency (58.1%), and drug release (up to 60%) under simulated biological environment conditions. In addition, the backbone structure of the biodegradable polymer was easily hydrolyzed by the action of biological enzymes. As expected, cell-based studies showed that the designed polymer micelles possessed good biocompatibility (a survival rate of 85% for NH-3T3 cells). Moreover, the drug (DOX) still maintained good anti-cancer effects after being loaded, which caused 40% of MCF-7 cells to survive. These redox-sensitive micelles showed anti-tumor therapeutic potential. View Full-Text
Keywords: adamantane; star; redox-sensitive; nanomicelles; biodegradable polymer adamantane; star; redox-sensitive; nanomicelles; biodegradable polymer
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Li, M.; Guo, J.-W.; Wen, W.-Q.; Chen, J.-K. Biodegradable Redox-Sensitive Star Polymer Nanomicelles for Enhancing Doxorubicin Delivery. Nanomaterials 2019, 9, 547.

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