Next Article in Journal
MOF-Derived Co3O4 Polyhedrons as Efficient Polysulfides Barrier on Polyimide Separators for High Temperature Lithium–sulfur Batteries
Previous Article in Journal
Facile Fabrication of Flower-Like BiOI/BiOCOOH p–n Heterojunctions for Highly Efficient Visible-Light-Driven Photocatalytic Removal of Harmful Antibiotics
Open AccessReview

Label-Free MicroRNA Optical Biosensors

Frank Reidy Research Center for Bioelectrics, Department of Electrical and Computer Engineering, Old Dominion University, Norfolk, VA 23508, USA
*
Author to whom correspondence should be addressed.
Nanomaterials 2019, 9(11), 1573; https://doi.org/10.3390/nano9111573
Received: 8 October 2019 / Revised: 29 October 2019 / Accepted: 31 October 2019 / Published: 6 November 2019
MicroRNAs (miRNAs) play crucial roles in regulating gene expression. Many studies show that miRNAs have been linked to almost all kinds of disease. In addition, miRNAs are well preserved in a variety of specimens, thereby making them ideal biomarkers for biosensing applications when compared to traditional protein biomarkers. Conventional biosensors for miRNA require fluorescent labeling, which is complicated, time-consuming, laborious, costly, and exhibits low sensitivity. The detection of miRNA remains a big challenge due to their intrinsic properties such as small sizes, low abundance, and high sequence similarity. A label-free biosensor can simplify the assay and enable the direct detection of miRNA. The optical approach for a label-free miRNA sensor is very promising and many assays have demonstrated ultra-sensitivity (aM) with a fast response time. Here, we review the most relevant label-free microRNA optical biosensors and the nanomaterials used to enhance the performance of the optical biosensors. View Full-Text
Keywords: microRNA; nanomaterials; label-free; optical sensor microRNA; nanomaterials; label-free; optical sensor
Show Figures

Figure 1

MDPI and ACS Style

Lai, M.; Slaughter, G. Label-Free MicroRNA Optical Biosensors. Nanomaterials 2019, 9, 1573.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop