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Open AccessArticle

3D-Printed Concentration-Controlled Microfluidic Chip with Diffusion Mixing Pattern for the Synthesis of Alginate Drug Delivery Microgels

1
School of Life Science and Technology, Xidian University, Xi’an 710126, Shaanxi, China
2
Kunpad Communication Pty. Ltd., Kunshan 215300, Jiangsu, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Nanomaterials 2019, 9(10), 1451; https://doi.org/10.3390/nano9101451
Received: 16 August 2019 / Revised: 3 October 2019 / Accepted: 11 October 2019 / Published: 12 October 2019
(This article belongs to the Special Issue 3D Printing and Nanotechnology in Biology and Medical Applications)
Alginate as a good drug delivery vehicle has excellent biocompatibility and biodegradability. In the ionic gelation process between alginate and Ca2+, the violent reaction is the absence of a well-controlled strategy in the synthesizing calcium alginate (CaA) microgels. In this study, a concentration-controlled microfluidic chip with central buffer flow was designed and 3D-printed to well-control the synthesis process of CaA microgels by the diffusion mixing pattern. The diffusion mixing pattern in the microfluidic chip can slow down the ionic gelation process in the central stream. The particle size can be influenced by channel length and flow rate ratio, which can be regulated to 448 nm in length and 235 nm in diameter. The delivery ratio of Doxorubicin (Dox) in CaA microgels are up to 90% based on the central stream strategy. [email protected] microgels with pH-dependent release property significantly enhances the cell killing rate against human breast cancer cells (MCF-7). The diffusion mixing pattern gives rise to well-controlled synthesis of CaA microgels, serving as a continuous and controllable production process for advanced drug delivery systems. View Full-Text
Keywords: 3D-printing; microfluidic chips; concentration controlled; diffusion mixing pattern; calcium alginate microgels 3D-printing; microfluidic chips; concentration controlled; diffusion mixing pattern; calcium alginate microgels
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MDPI and ACS Style

Cai, S.; Shi, H.; Li, G.; Xue, Q.; Zhao, L.; Wang, F.; Hu, B. 3D-Printed Concentration-Controlled Microfluidic Chip with Diffusion Mixing Pattern for the Synthesis of Alginate Drug Delivery Microgels. Nanomaterials 2019, 9, 1451.

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