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Nanomaterials 2018, 8(7), 511;

Lanthanide-Doped Upconversion Nanocarriers for Drug and Gene Delivery

School of Chemical Engineering, Chonnam National University, Gwangju 61186, Korea
Author to whom correspondence should be addressed.
Received: 4 June 2018 / Revised: 6 July 2018 / Accepted: 7 July 2018 / Published: 9 July 2018
(This article belongs to the Special Issue Biomedical Applications of Nanoparticles)
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Compared to traditional cancer treatments, drug/gene delivery is an advanced, safe, and efficient method. Nanoparticles are widely used as nanocarriers in a drug/gene delivery system due to their long circulation time and low multi-drug resistance. In particular, lanthanide-doped upconversion nanoparticles (UCNPs) that can emit UV and visible light by near-infrared (NIR) upconversion demonstrated more efficient and safer drug/gene delivery. Because of the low penetration depth of UV and visible light, a photoinduced reaction such as photocleavage or photoisomerization has proven restrictive. However, NIR light has high tissue penetration depth and stimulates the photoinduced reaction through UV and visible emissions from lanthanide-doped UCNPs. This review discusses the optical properties of UCNPs that are useful in bioapplications and drug/gene delivery systems using the UCNPs as a photoreaction inducer. View Full-Text
Keywords: upconversion nanoparticles; nanocarriers; drug delivery; gene delivery; photolysis upconversion nanoparticles; nanocarriers; drug delivery; gene delivery; photolysis

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Lee, G.; Park, Y.I. Lanthanide-Doped Upconversion Nanocarriers for Drug and Gene Delivery. Nanomaterials 2018, 8, 511.

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