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Nanomaterials 2018, 8(4), 235; https://doi.org/10.3390/nano8040235

Fabrication of Sericin/Agrose Gel Loaded Lysozyme and Its Potential in Wound Dressing Application

1
State Key Laboratory of Silkworm Genome Biology, Southwest University, Beibei, Chongqing 400715, China
2
College of Biotechnology, Southwest University, Beibei, Chongqing 400715, China
3
College of Pharmaceutical Sciences, Southwest University, Beibei, Chongqing 400715, China
4
Chongqing Engineering and Technology Research Center for Novel Silk Materials, Southwest University, Beibei, Chongqing 400715, China
5
Department of Chemistry, College of Science and Arts and Promising Centre for Sensors and Electronics Devices (PCSED), Najran University, P.O. Box 1988, Najran 11001, Saudi Arabia
6
Department of Chemistry & Biochemistry, Stephenson Life Science Research Center, University of Oklahoma, 101 Stephenson Parkway, Norman, OK 73019, USA
7
School of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, China
*
Authors to whom correspondence should be addressed.
Received: 6 March 2018 / Revised: 24 March 2018 / Accepted: 4 April 2018 / Published: 13 April 2018
(This article belongs to the Special Issue Design and Development of Nanostructured Thin Films)
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Abstract

Sericin is a biomaterial resource for its significant biodegradability, biocompatibility, hydrophilicity, and reactivity. Designing a material with superabsorbent, antiseptic, and non-cytotoxic wound dressing properties is advantageous to reduce wound infection and promote wound healing. Herein, we propose an environment-friendly strategy to obtain an interpenetrating polymer network gel through blending sericin and agarose and freeze-drying. The physicochemical characterizations of the sericin/agarose gel including morphology, porosity, swelling behavior, crystallinity, secondary structure, and thermal property were well characterized. Subsequently, the lysozyme loaded sericin/agarose composite gel was successfully prepared by the solution impregnation method. To evaluate the potential of the lysozyme loaded sericin/agarose gel in wound dressing application, we analyzed the lysozyme loading and release, antimicrobial activity, and cytocompatibility of the resulting gel. The results showed the lysozyme loaded composite gel had high porosity, excellent water absorption property, and good antimicrobial activities against Escherichia coli and Staphylococcus aureus. Also, the lysozyme loaded gel showed excellent cytocompatibility on NIH3T3 and HEK293 cells. So, the lysozyme loaded sericin/agarose gel is a potential alternative biomaterial for wound dressing. View Full-Text
Keywords: silk sericin; agarose; lysozyme; composite gel; wound dressing silk sericin; agarose; lysozyme; composite gel; wound dressing
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Yang, M.; Wang, Y.; Tao, G.; Cai, R.; Wang, P.; Liu, L.; Ai, L.; Zuo, H.; Zhao, P.; Umar, A.; Mao, C.; He, H. Fabrication of Sericin/Agrose Gel Loaded Lysozyme and Its Potential in Wound Dressing Application. Nanomaterials 2018, 8, 235.

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