Next Article in Journal
Optoelectronic and Electrochemical Properties of Vanadium Pentoxide Nanowires Synthesized by Vapor-Solid Process
Next Article in Special Issue
Metallic Nanostructures Based on DNA Nanoshapes
Previous Article in Journal
Synthesis of p-Co3O4/n-TiO2 Nanoparticles for Overall Water Splitting under Visible Light Irradiation
Previous Article in Special Issue
Structural Changes Induced in Grapevine (Vitis vinifera L.) DNA by Femtosecond IR Laser Pulses: A Surface-Enhanced Raman Spectroscopic Study
Article Menu

Export Article

Open AccessFeature PaperReview

DNA-Based Enzyme Reactors and Systems

Biohybrid Materials, Department of Biotechnology and Chemical Technology, Aalto University, P.O. Box 16100, Aalto 00076, Finland
Department of Physics, University of Jyvaskyla, Nanoscience Center, P.O. Box 35, Jyväskylä 40014, Finland
Authors to whom correspondence should be addressed.
Academic Editor: Leonid Gurevich
Nanomaterials 2016, 6(8), 139;
Received: 8 June 2016 / Revised: 11 July 2016 / Accepted: 19 July 2016 / Published: 27 July 2016
(This article belongs to the Special Issue DNA-Based Nanotechnology)
PDF [2132 KB, uploaded 27 July 2016]


During recent years, the possibility to create custom biocompatible nanoshapes using DNA as a building material has rapidly emerged. Further, these rationally designed DNA structures could be exploited in positioning pivotal molecules, such as enzymes, with nanometer-level precision. This feature could be used in the fabrication of artificial biochemical machinery that is able to mimic the complex reactions found in living cells. Currently, DNA-enzyme hybrids can be used to control (multi-enzyme) cascade reactions and to regulate the enzyme functions and the reaction pathways. Moreover, sophisticated DNA structures can be utilized in encapsulating active enzymes and delivering the molecular cargo into cells. In this review, we focus on the latest enzyme systems based on novel DNA nanostructures: enzyme reactors, regulatory devices and carriers that can find uses in various biotechnological and nanomedical applications. View Full-Text
Keywords: DNA nanotechnology; DNA origami; self-assembly; enzyme; cascade reactions; DNA nanodevice; DNA sensors; drug-delivery; nanomedicine DNA nanotechnology; DNA origami; self-assembly; enzyme; cascade reactions; DNA nanodevice; DNA sensors; drug-delivery; nanomedicine

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Linko, V.; Nummelin, S.; Aarnos, L.; Tapio, K.; Toppari, J.J.; Kostiainen, M.A. DNA-Based Enzyme Reactors and Systems. Nanomaterials 2016, 6, 139.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Nanomaterials EISSN 2079-4991 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top