Next Article in Journal
Preparation and Characterization of a Glycyrrhizic Acid-Based Drug Delivery System for Allergen-Specific Immunotherapy
Next Article in Special Issue
Assessing Genotoxicity of Ten Different Engineered Nanomaterials by the Novel Semi-Automated FADU Assay and the Alkaline Comet Assay
Previous Article in Journal
Single Step Laser-Induced Deposition of Plasmonic Au, Ag, Pt Mono-, Bi- and Tri-Metallic Nanoparticles
Previous Article in Special Issue
Agglomeration State of Titanium-Dioxide (TiO2) Nanomaterials Influences the Dose Deposition and Cytotoxic Responses in Human Bronchial Epithelial Cells at the Air-Liquid Interface
Article

Comparison of Metal-Based Nanoparticles and Nanowires: Solubility, Reactivity, Bioavailability and Cellular Toxicity

1
Department of Food Chemistry and Toxicology, Faculty of Chemistry and Biosciences, Institute of Applied Biosciences, Karlsruhe Institute of Technology (KIT), 76131 Karlsruhe, Germany
2
BASF SE, 67063 Ludwigshafen, Germany
3
Fraunhofer ITEM, 30625 Hannover, Germany
4
ToxConsultant, 30625 Hannover, Germany
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Bing Yan and Zhanjun Gu
Nanomaterials 2022, 12(1), 147; https://doi.org/10.3390/nano12010147
Received: 22 November 2021 / Revised: 21 December 2021 / Accepted: 28 December 2021 / Published: 31 December 2021
(This article belongs to the Special Issue Risk Assessment of Nanomaterials Toxicity)
While the toxicity of metal-based nanoparticles (NP) has been investigated in an increasing number of studies, little is known about metal-based fibrous materials, so-called nanowires (NWs). Within the present study, the physico-chemical properties of particulate and fibrous nanomaterials based on Cu, CuO, Ni, and Ag as well as TiO2 and CeO2 NP were characterized and compared with respect to abiotic metal ion release in different physiologically relevant media as well as acellular reactivity. While none of the materials was soluble at neutral pH in artificial alveolar fluid (AAF), Cu, CuO, and Ni-based materials displayed distinct dissolution under the acidic conditions found in artificial lysosomal fluids (ALF and PSF). Subsequently, four different cell lines were applied to compare cytotoxicity as well as intracellular metal ion release in the cytoplasm and nucleus. Both cytotoxicity and bioavailability reflected the acellular dissolution rates in physiological lysosomal media (pH 4.5); only Ag-based materials showed no or very low acellular solubility, but pronounced intracellular bioavailability and cytotoxicity, leading to particularly high concentrations in the nucleus. In conclusion, in spite of some quantitative differences, the intracellular bioavailability as well as toxicity is mostly driven by the respective metal and is less modulated by the shape of the respective NP or NW. View Full-Text
Keywords: metal-based nanoparticles and nanowires; solubility; intracellular bioavailability; oxidative reactivity metal-based nanoparticles and nanowires; solubility; intracellular bioavailability; oxidative reactivity
Show Figures

Figure 1

MDPI and ACS Style

Wall, J.; Seleci, D.A.; Schworm, F.; Neuberger, R.; Link, M.; Hufnagel, M.; Schumacher, P.; Schulz, F.; Heinrich, U.; Wohlleben, W.; Hartwig, A. Comparison of Metal-Based Nanoparticles and Nanowires: Solubility, Reactivity, Bioavailability and Cellular Toxicity. Nanomaterials 2022, 12, 147. https://doi.org/10.3390/nano12010147

AMA Style

Wall J, Seleci DA, Schworm F, Neuberger R, Link M, Hufnagel M, Schumacher P, Schulz F, Heinrich U, Wohlleben W, Hartwig A. Comparison of Metal-Based Nanoparticles and Nanowires: Solubility, Reactivity, Bioavailability and Cellular Toxicity. Nanomaterials. 2022; 12(1):147. https://doi.org/10.3390/nano12010147

Chicago/Turabian Style

Wall, Johanna, Didem A. Seleci, Feranika Schworm, Ronja Neuberger, Martin Link, Matthias Hufnagel, Paul Schumacher, Florian Schulz, Uwe Heinrich, Wendel Wohlleben, and Andrea Hartwig. 2022. "Comparison of Metal-Based Nanoparticles and Nanowires: Solubility, Reactivity, Bioavailability and Cellular Toxicity" Nanomaterials 12, no. 1: 147. https://doi.org/10.3390/nano12010147

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop