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Communication

Nano-Topographical Control of Ti-Nb-Zr Alloy Surfaces for Enhanced Osteoblastic Response

1
Department of Materials Science and Engineering, Seoul National University, Seoul 08826, Korea
2
Department of Materials Science and Engineering and Querrey-Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA
3
Department of Biomedical-Chemical Engineering, Catholic University of Korea, Bucheon 14662, Korea
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Department of Biotechnology, The Catholic University of Korea, Bucheon 14662, Korea
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Department of Nano-Biomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan 31116, Korea
6
Department of Materials Science and Engineering, Chosun University, Gwangju 61452, Korea
*
Authors to whom correspondence should be addressed.
Academic Editors: Hicham Fenniri and Junghwan Lee
Nanomaterials 2021, 11(6), 1507; https://doi.org/10.3390/nano11061507
Received: 24 April 2021 / Revised: 27 May 2021 / Accepted: 2 June 2021 / Published: 7 June 2021
(This article belongs to the Special Issue Nanomaterials and Nanotechnology for Regenerative Medicine)
Nano-scale surface roughening of metallic bio-implants plays an important role in the clinical success of hard tissue reconstruction and replacement. In this study, the nano-topographical features of titanium-niobium-zirconium (TNZ) alloy surfaces were controlled by using the target-ion induced plasma sputtering (TIPS) technique to improve the in vitro osteoblastic response. The TIPS technique is a novel strategy for etching the surface of metallic bio-implants using bombardment of target metal cations, which were accelerated by an extremely high negative bias voltage applied to the substrates. The nano-topography of the TNZ surfaces was successfully controlled by modulating experimental variables (such as the ion etching energy and the type of substrate or target materials) of TIPS. As a result, various nanopatterns (size: 10–210 nm) were fabricated on the surface of the TNZ alloys. Compared with the control group, experimental groups with nanopattern widths of ≥130 nm (130 and 210 nm groups) exhibited superior cell adhesion, proliferation, and differentiation. Our findings demonstrate that TIPS is a promising technology that can impart excellent biological functions to the surface of metallic bio-implants. View Full-Text
Keywords: Ti-based alloy; ion etching; nano-topography; biocompatibility; biomedical implants Ti-based alloy; ion etching; nano-topography; biocompatibility; biomedical implants
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MDPI and ACS Style

Lee, M.-K.; Lee, H.; Kim, H.-E.; Lee, E.-J.; Jang, T.-S.; Jung, H.-D. Nano-Topographical Control of Ti-Nb-Zr Alloy Surfaces for Enhanced Osteoblastic Response. Nanomaterials 2021, 11, 1507. https://doi.org/10.3390/nano11061507

AMA Style

Lee M-K, Lee H, Kim H-E, Lee E-J, Jang T-S, Jung H-D. Nano-Topographical Control of Ti-Nb-Zr Alloy Surfaces for Enhanced Osteoblastic Response. Nanomaterials. 2021; 11(6):1507. https://doi.org/10.3390/nano11061507

Chicago/Turabian Style

Lee, Min-Kyu, Hyun Lee, Hyoun-Ee Kim, Eun-Jung Lee, Tae-Sik Jang, and Hyun-Do Jung. 2021. "Nano-Topographical Control of Ti-Nb-Zr Alloy Surfaces for Enhanced Osteoblastic Response" Nanomaterials 11, no. 6: 1507. https://doi.org/10.3390/nano11061507

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