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Article

PCN-224 Nanoparticle/Polyacrylonitrile Nanofiber Membrane for Light-Driven Bacterial Inactivation

1
Key Laboratory of Eco-Textiles, Ministry of Education, Jiangnan University, Wuxi 214122, China
2
Textile Processing Department, Faculty of Engineering & Technology, National Textile University, Faisalabad 37610, Pakistan
*
Author to whom correspondence should be addressed.
Academic Editor: Lyudmila M. Bronstein
Nanomaterials 2021, 11(12), 3162; https://doi.org/10.3390/nano11123162
Received: 6 November 2021 / Revised: 18 November 2021 / Accepted: 19 November 2021 / Published: 23 November 2021
(This article belongs to the Special Issue New Frontiers of Flexible and Wearable Nanosensors)
Increasing issues of pathogen drug resistance and spreading pose a serious threat to the ability to treat common infectious diseases, which encourages people to explore effective technology to meet the challenge. Photodynamic antibacterial inactivation (aPDI) is being explored for inactivating pathogens, which could be used as a novel approach to prevent this threat. Here, porphyrin-embedded MOF material (PCN-224) with photodynamic effect was synthesized, then the PCN-224 nanoparticles (NPs) were embedded into PAN nanofibers with an electrospinning process (PAN-PCN nanofiber membrane). On the one hand, polyacrylonitrile (PAN) nanofibers help to improve the stability of PCN-224 NPs, which could avoid their leakage. On the other, the PAN nanofibers are used as a support material to load bactericidal PCN-224 NPs, realizing recycling after bacterial elimination. An antibacterial photodynamic inactivation (aPDI) study demonstrated that the PAN-PCN 0.6% nanofiber membrane processed 3.00 log unit elimination towards a E. coli bacterial strain and 4.70 log unit towards a S. aureus strain under illumination. A mechanism study revealed that this efficient bacterial elimination was due to singlet oxygen (1O2). Although the materials are highly phototoxic, an MTT assay showed that the as fabricated nanofiber membranes had good biocompatibility in the dark, and the cell survival rates were all above 85%. Taken together, this work provided an application prospect of nanofibers with an aPDI effect to deal with the issues of pathogen drug resistance and spreading. View Full-Text
Keywords: electrospinning; antibacterial photodynamic inactivation; PCN-224; polyacrylonitrile; singlet oxygen electrospinning; antibacterial photodynamic inactivation; PCN-224; polyacrylonitrile; singlet oxygen
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MDPI and ACS Style

Nie, X.; Wu, S.; Hussain, T.; Wei, Q. PCN-224 Nanoparticle/Polyacrylonitrile Nanofiber Membrane for Light-Driven Bacterial Inactivation. Nanomaterials 2021, 11, 3162. https://doi.org/10.3390/nano11123162

AMA Style

Nie X, Wu S, Hussain T, Wei Q. PCN-224 Nanoparticle/Polyacrylonitrile Nanofiber Membrane for Light-Driven Bacterial Inactivation. Nanomaterials. 2021; 11(12):3162. https://doi.org/10.3390/nano11123162

Chicago/Turabian Style

Nie, Xiaolin, Shuanglin Wu, Tanveer Hussain, and Qufu Wei. 2021. "PCN-224 Nanoparticle/Polyacrylonitrile Nanofiber Membrane for Light-Driven Bacterial Inactivation" Nanomaterials 11, no. 12: 3162. https://doi.org/10.3390/nano11123162

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