Next Article in Journal
Sono-Assembly of the [Arg-Phe]4 Octapeptide into Biofunctional Nanoparticles
Next Article in Special Issue
Imaging and Characterization of Sustained Gadolinium Nanoparticle Release from Next Generation Radiotherapy Biomaterial
Previous Article in Journal
Nanomaterials in Dentistry: State of the Art and Future Challenges
Previous Article in Special Issue
Fluorescent, Prussian Blue-Based Biocompatible Nanoparticle System for Multimodal Imaging Contrast
Review

Nanoparticles for Cerenkov and Radioluminescent Light Enhancement for Imaging and Radiotherapy

1
Department of Computer Science, University of Verona, Strada Le Grazie 15, 37134 Verona, Italy
2
Experimental Imaging Center, San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy
*
Author to whom correspondence should be addressed.
Nanomaterials 2020, 10(9), 1771; https://doi.org/10.3390/nano10091771
Received: 4 August 2020 / Revised: 1 September 2020 / Accepted: 2 September 2020 / Published: 7 September 2020
(This article belongs to the Special Issue Nanomaterials for Contrast Agent and Biomedical Imaging)
Cerenkov luminescence imaging and Cerenkov photodynamic therapy have been developed in recent years to exploit the Cerenkov radiation (CR) generated by radioisotopes, frequently used in Nuclear Medicine, to diagnose and fight cancer lesions. For in vivo detection, the endpoint energy of the radioisotope and, thus, the total number of the emitted Cerenkov photons, represents a very important variable and explains why, for example, 68Ga is better than 18F. However, it was also found that the scintillation process is an important mechanism for light production. Nanotechnology represents the most important field, providing nanosctructures which are able to shift the UV-blue emission into a more suitable wavelength, with reduced absorption, which is useful especially for in vivo imaging and therapy applications. Nanoparticles can be made, loaded or linked to fluorescent dyes to modify the optical properties of CR radiation. They also represent a useful platform for therapeutic agents, such as photosensitizer drugs for the production of reactive oxygen species (ROS). Generally, NPs can be spaced by CR sources; however, for in vivo imaging applications, NPs bound to or incorporating radioisotopes are the most interesting nanocomplexes thanks to their high degree of mutual colocalization and the reduced problem of false uptake detection. Moreover, the distance between the NPs and CR source is crucial for energy conversion. Here, we review the principal NPs proposed in the literature, discussing their properties and the main results obtained by the proponent experimental groups. View Full-Text
Keywords: nanoparticles; nanocompounds; nanoclusters; cerenkov radiation; cerenkov luminescence imaging; photodynamic therapy; gold nanoparticles; silica nanoparticles; rare-earth nanoparticles nanoparticles; nanocompounds; nanoclusters; cerenkov radiation; cerenkov luminescence imaging; photodynamic therapy; gold nanoparticles; silica nanoparticles; rare-earth nanoparticles
Show Figures

Graphical abstract

MDPI and ACS Style

Boschi, F.; Spinelli, A.E. Nanoparticles for Cerenkov and Radioluminescent Light Enhancement for Imaging and Radiotherapy. Nanomaterials 2020, 10, 1771. https://doi.org/10.3390/nano10091771

AMA Style

Boschi F, Spinelli AE. Nanoparticles for Cerenkov and Radioluminescent Light Enhancement for Imaging and Radiotherapy. Nanomaterials. 2020; 10(9):1771. https://doi.org/10.3390/nano10091771

Chicago/Turabian Style

Boschi, Federico, and Antonello E. Spinelli 2020. "Nanoparticles for Cerenkov and Radioluminescent Light Enhancement for Imaging and Radiotherapy" Nanomaterials 10, no. 9: 1771. https://doi.org/10.3390/nano10091771

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop