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Article

Effect of Flavonoid-Coated Gold Nanoparticles on Bacterial Colonization in Mice Organs

1
Department of Biomedical Engineering and Sciences, School of Mechanical & Manufacturing Engineering, National University of Sciences & Technology, Islamabad 44000, Pakistan
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Ministry of National Food Security and Research, Pakistan Agricultural Research Council, Karachi 75270, Pakistan
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School of Science and Engineering, Lahore University of Management Sciences, Lahore 54000, Pakistan
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Department of Internal Medicine and Nanomedicine, California Innovations Corporation, San Diego, CA 92093, USA
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Atta Ur Rahman School of Applied Biosciences, National University of Sciences & Technology, Islamabad 44000, Pakistan
*
Author to whom correspondence should be addressed.
Nanomaterials 2020, 10(9), 1769; https://doi.org/10.3390/nano10091769
Received: 16 June 2020 / Revised: 25 July 2020 / Accepted: 28 July 2020 / Published: 7 September 2020
(This article belongs to the Section Biology and Medicines)
Multidrug resistance (MDR) has been a potentiator for the exploration of antibiotics. Nano drug delivery systems have opened new avenues to overcome this challenge. Although antibacterial nanocarriers are extensively realized, their effect on the bacteria residing inside the tissues and their toxicity is rarely explored. This study investigated the effects of flavonoid coated gold nanoparticles (FAuNPs) on the colonization of Enterococcus faecalis in the mouse liver and kidneys. Flavonoids were extracted from the leaves of Berberis lycium Royle and used to stabilize gold following a green synthesis approach. FAuNPs were characterized by ultraviolet-visible (UV-Vis) spectroscopy, Fourier-transform infrared spectroscopy (FTIR), scanning transmission electron microscopy (STEM), X-ray powder diffraction (XRD), and energy-dispersive X-ray spectroscopy (EDS). FAuNPs showed significantly higher reduction in bacterial counts in in-vitro and in-vivo in mice organs as compared to the free flavonoids owing to their biocompatibility and effectiveness. View Full-Text
Keywords: flavonoids; Berberis lycium; Enterococcus faecalis; drug delivery; infectious diseases flavonoids; Berberis lycium; Enterococcus faecalis; drug delivery; infectious diseases
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MDPI and ACS Style

Riaz, S.; Fatima Rana, N.; Hussain, I.; Tanweer, T.; Nawaz, A.; Menaa, F.; Janjua, H.A.; Alam, T.; Batool, A.; Naeem, A.; Hameed, M.; Ali, S.M. Effect of Flavonoid-Coated Gold Nanoparticles on Bacterial Colonization in Mice Organs. Nanomaterials 2020, 10, 1769. https://doi.org/10.3390/nano10091769

AMA Style

Riaz S, Fatima Rana N, Hussain I, Tanweer T, Nawaz A, Menaa F, Janjua HA, Alam T, Batool A, Naeem A, Hameed M, Ali SM. Effect of Flavonoid-Coated Gold Nanoparticles on Bacterial Colonization in Mice Organs. Nanomaterials. 2020; 10(9):1769. https://doi.org/10.3390/nano10091769

Chicago/Turabian Style

Riaz, Sundus, Nosheen Fatima Rana, Irshad Hussain, Tahreem Tanweer, Afrah Nawaz, Farid Menaa, Hussnain A. Janjua, Tahseen Alam, Amna Batool, Ayesha Naeem, Maryam Hameed, and Syed M. Ali 2020. "Effect of Flavonoid-Coated Gold Nanoparticles on Bacterial Colonization in Mice Organs" Nanomaterials 10, no. 9: 1769. https://doi.org/10.3390/nano10091769

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