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Article

pH-Responsive Resveratrol-Loaded Electrospun Membranes for the Prevention of Implant-Associated Infections

1
Institute for Polymers, Composites and Biomaterials (IPCB-CNR) Via Campi Flegrei, 34, 80078 Pozzuoli (NA), Italy
2
Elleva Pharma S.R.L. Via Pietro Castellino, 111, 80131 Naples, Italy
3
Research Institute on Terrestrial Ecosystems (IRET)—CNR, Via Pietro Castellino 111, 80131 Naples, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Nanomaterials 2020, 10(6), 1175; https://doi.org/10.3390/nano10061175
Received: 7 May 2020 / Revised: 10 June 2020 / Accepted: 12 June 2020 / Published: 16 June 2020
(This article belongs to the Special Issue Responsive Polymer Nanoparticles and Nanocomposites)
To date, the implant-associated infections represent a worldwide challenge for the recently reported bacterial drug resistance that can lead to the inefficacy or low efficacy of conventional antibiotic therapies. Plant polyphenolic compounds, including resveratrol (RSV), are increasingly gaining consensus as valid and effective alternatives to antibiotics limiting antibiotic resistance. In this study, electrospun polylactic acid (PLA) membranes loaded with different concentrations of RSV are synthesized and characterized in their chemical, morphological, and release features. The obtained data show that the RSV release rate from the PLA-membranes is remarkably higher in acidic conditions than at neutral pH. In addition, a change in pH from neutral to slightly acidic triggers a significant increase in the RSV release. This behavior indicates that the PLA-RSV membranes can act as drug reservoir when the environmental pH is neutral, starting to release the bioactive molecules when the pH decreases, as in presence of oral bacterial infection. Indeed, our results demonstrate that PLA-RSV2 displays a significant antibacterial and antibiofilm activity against two bacterial strains, Pseudomonas aeruginosa PAO1, and Streptococcus mutans, responsible for both acute and chronic infections in humans, thus representing a promising solution for the prevention of the implant-associated infections. View Full-Text
Keywords: bioresorbable membrane; phytochemicals; resveratrol; polylactic acid; electrospinning; antibiofilm bioresorbable membrane; phytochemicals; resveratrol; polylactic acid; electrospinning; antibiofilm
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MDPI and ACS Style

Bonadies, I.; Di Cristo, F.; Valentino, A.; Peluso, G.; Calarco, A.; Di Salle, A. pH-Responsive Resveratrol-Loaded Electrospun Membranes for the Prevention of Implant-Associated Infections. Nanomaterials 2020, 10, 1175. https://doi.org/10.3390/nano10061175

AMA Style

Bonadies I, Di Cristo F, Valentino A, Peluso G, Calarco A, Di Salle A. pH-Responsive Resveratrol-Loaded Electrospun Membranes for the Prevention of Implant-Associated Infections. Nanomaterials. 2020; 10(6):1175. https://doi.org/10.3390/nano10061175

Chicago/Turabian Style

Bonadies, Irene, Francesca Di Cristo, Anna Valentino, Gianfranco Peluso, Anna Calarco, and Anna Di Salle. 2020. "pH-Responsive Resveratrol-Loaded Electrospun Membranes for the Prevention of Implant-Associated Infections" Nanomaterials 10, no. 6: 1175. https://doi.org/10.3390/nano10061175

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