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Open AccessArticle

Attachment Efficiency of Nanomaterials to Algae as an Important Criterion for Ecotoxicity and Grouping

1
Fraunhofer Institute for Molecular Biology and Applied Ecology, Auf dem Aberg 1, 57392 Schmallenberg, Germany
2
Institute for Energy and Environmental Technology, e.V. (IUTA), Bliersheimer Straße 58-60, 47229 Duisburg, Germany
3
Helmholtz Centre for Environmental Research—UFZ, Permoserstr. 15, 04318 Leipzig, Germany
*
Author to whom correspondence should be addressed.
Nanomaterials 2020, 10(6), 1021; https://doi.org/10.3390/nano10061021
Received: 6 March 2020 / Revised: 4 April 2020 / Accepted: 20 May 2020 / Published: 27 May 2020
(This article belongs to the Special Issue Toxicology and Biocompatibility of Nanomaterials)
Engineered nanomaterials (ENMs) based on CeO2 and TiO2 differ in their effects on the unicellular green alga Raphidocelis subcapitata but these effects do not reflect the physicochemical parameters that characterize such materials in water and other test media. To determine whether interactions with algae can predict the ecotoxicity of ENMs, we studied the attachment of model compounds (three subtypes of CeO2 and five subtypes of TiO2) to algal cells by light microscopy and electron microscopy. We correlated our observations with EC50 values determined in growth inhibition assays carried out according to the Organisation for Economic Co-operation and Development (OECD) test guideline 201. Light microscopy revealed distinct patterns of ENM attachment to algal cells according to the type of compound, with stronger interactions leading to greater toxicity. This was confirmed by electron microscopy, which allowed the quantitative assessment of particle attachment. Our results indicate that algal extracellular polymeric substances play an important role in the attachment of ENMs, influencing the formation of agglomerates. The attachment parameters in short-term tests predicted the toxicity of CeO2 and TiO2 ENMs and can be considered as a valuable tool for the identification of sets of similar nanoforms as requested by the European Chemicals Agency in the context of grouping and read-across. View Full-Text
Keywords: nanotoxicology; European Chemicals Agency (ECHA); ecotoxicology; nanoparticles; aggregation; Raphidocelis subcapitata nanotoxicology; European Chemicals Agency (ECHA); ecotoxicology; nanoparticles; aggregation; Raphidocelis subcapitata
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MDPI and ACS Style

Hund-Rinke, K.; Sinram, T.; Schlich, K.; Nickel, C.; Dickehut, H.P.; Schmidt, M.; Kühnel, D. Attachment Efficiency of Nanomaterials to Algae as an Important Criterion for Ecotoxicity and Grouping. Nanomaterials 2020, 10, 1021. https://doi.org/10.3390/nano10061021

AMA Style

Hund-Rinke K, Sinram T, Schlich K, Nickel C, Dickehut HP, Schmidt M, Kühnel D. Attachment Efficiency of Nanomaterials to Algae as an Important Criterion for Ecotoxicity and Grouping. Nanomaterials. 2020; 10(6):1021. https://doi.org/10.3390/nano10061021

Chicago/Turabian Style

Hund-Rinke, Kerstin; Sinram, Tim; Schlich, Karsten; Nickel, Carmen; Dickehut, Hanna P.; Schmidt, Matthias; Kühnel, Dana. 2020. "Attachment Efficiency of Nanomaterials to Algae as an Important Criterion for Ecotoxicity and Grouping" Nanomaterials 10, no. 6: 1021. https://doi.org/10.3390/nano10061021

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