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Open AccessArticle

Incorporation of Lippia citriodora Microwave Extract into Total-Green Biogelatin-Phospholipid Vesicles to Improve Its Antioxidant Activity

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Functional Food Research and Development Center, Health Science Technological Park, Avenida del Conocimiento s/n, E-18016 Granada, Spain
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Department of Scienze della Vita e dell’Ambiente, University of Cagliari, via Ospedale 72, 09124 Cagliari, Italy
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Group of Recycling and Valorization of Waste Materials (REVAL), Marine Research Institute (IIM-CSIC), C/Eduardo Cabello, 6, CP36208 Vigo, Spain
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Department of Food Science and Nutrition, University of Granada, Campus of Cartuja, 18011 Granada, Spain
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Biopharmaceutics and Pharmacokinetics Unit, Institute for Nanoscience and Nanotechnology, University of Barcelona, 08193 Barcelona, Spain
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CIBER Physiopathology of Obesity and Nutrition (CIBEROBN), Institute of Health Carlos III, 28029 Madrid, Spain
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Department of Analytical Chemistry, Faculty of Sciences, University of Granada, Fuentenueva s/n, E-18071 Granada, Spain
*
Author to whom correspondence should be addressed.
Nanomaterials 2020, 10(4), 765; https://doi.org/10.3390/nano10040765
Received: 24 February 2020 / Revised: 4 April 2020 / Accepted: 13 April 2020 / Published: 16 April 2020
(This article belongs to the Special Issue Nanocarriers and Targeted Drug Delivery)
Phytochemicals from Lippia citriodora leaves were extracted by applying an innovative technology based on the use of microwaves, which represents an alternative method to extract bioactive substances. The obtained extract was incorporated into phospholipid vesicles in order to promote the antioxidant effect of the bioactive molecules present in L. citriodora extract. The extract was analyzed by High Performance Liquid Chromatography coupled to Time-Of-Flight mass spectrometer by electrospray (HPLC-ESI-TOF-MS) and different phytochemicals were detected and quantified. The whole extract was incorporated in liposomes, glycerosomes (liposomes modified with glycerol) and propylene glycol-containing vesicles (PG-PEVs). Moreover, a biopolymer obtained from fish by-product, that is Thunnus albacares skin, was added to improve the bioactivity of the formulations. The in vitro biocompatibility and the antioxidant efficacy of the extract in solution or loaded in the vesicles were tested in primary mouse embryonic fibroblasts (3T3). The results showed the superior bioactivity of the vesicle formulations over the aqueous solution of the extract, which points to an interesting strategy for the treatment of skin disorders. View Full-Text
Keywords: Lippia citriodora; green extract; phospholipid vesicles; antioxidant; Thunnus albacares; skin delivery Lippia citriodora; green extract; phospholipid vesicles; antioxidant; Thunnus albacares; skin delivery
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MDPI and ACS Style

Leyva-Jiménez, F.J.; Manca, M.L.; Manconi, M.; Caddeo, C.; Vázquez, J.A.; Lozano-Sánchez, J.; Escribano-Ferrer, E.; Arráez-Román, D.; Segura-Carretero, A. Incorporation of Lippia citriodora Microwave Extract into Total-Green Biogelatin-Phospholipid Vesicles to Improve Its Antioxidant Activity. Nanomaterials 2020, 10, 765.

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