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Open AccessArticle

Nano Zinc Oxide Induced Fetal Mice Growth Restriction, Based on Oxide Stress and Endoplasmic Reticulum Stress

1
State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China
2
Zystein, LLC., Fayetteville, AR 72703, USA
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Nanomaterials 2020, 10(2), 259; https://doi.org/10.3390/nano10020259
Received: 22 November 2019 / Revised: 23 January 2020 / Accepted: 31 January 2020 / Published: 2 February 2020
(This article belongs to the Special Issue Sustainable Design for Safer Nanotechnology)
ZnO NPs have been assessed to show adverse effects on reproductive organs, but the molecular mechanisms of reproductive toxicity have not been sufficiently studied. In this research, the dosage effects from the oral exposure of ZnO NPs (30 nm) to pregnant mice in gestation day 10.5 to 17.5 was analyzed. Pregnant mice exposed to ZnO NPs induced dam injury, mice fetal growth restriction, and the fetus number decreased. The pathological evaluation showed that ZnO NPs exposure caused placental spongiotrophoblast area decease and structural damage. The RT-qPCR and immunocytochemistry data indicated that ZnO NPs could induce placenta oxide stress, endoplasmic reticulum stress responses, apoptosis, and altered placental function. These findings indicated that ZnO NPs could induce dam injury and fetal growth restriction. Reproductive toxicity of ZnO NPs may be due to placental injury and function alteration caused by apoptosis, oxide stress, and endoplasmic reticulum stress after ZnO NPs exposure. View Full-Text
Keywords: zinc oxide nanoparticles; dosage; fetal growth restriction; endoplasmic reticulum stress; reproductive toxicity zinc oxide nanoparticles; dosage; fetal growth restriction; endoplasmic reticulum stress; reproductive toxicity
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MDPI and ACS Style

Chen, B.; Hong, W.; Yang, P.; Tang, Y.; Zhao, Y.; Aguilar, Z.P.; Xu, H. Nano Zinc Oxide Induced Fetal Mice Growth Restriction, Based on Oxide Stress and Endoplasmic Reticulum Stress. Nanomaterials 2020, 10, 259.

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