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Article

Effective Detection of Nafion®-Based Theranostic Nanocapsules Through 19F Ultra-Short Echo Time MRI

1
Institute of Nuclear Physics, Polish Academy of Sciences, 31–342 Krakow, Poland
2
Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences, 30–239 Krakow, Poland
*
Author to whom correspondence should be addressed.
Nanomaterials 2020, 10(11), 2127; https://doi.org/10.3390/nano10112127
Received: 9 September 2020 / Revised: 9 October 2020 / Accepted: 18 October 2020 / Published: 26 October 2020
(This article belongs to the Special Issue Functional Polymeric Nanoparticles)
The application of the Three-Dimensional Ultra-Short Echo Time (3D UTE)pulse sequence at a high magnetic field for visualization of the distribution of 19F loaded theranostic core-shell nanocapsules with Nafion® (1,1,2,2-tetrafluoroethene; 1,1,2,2-tetrafluoro-2- [1,1,1,2,3,3-hexafluoro-3-(1,2,2-trifluoroethenoxy)propan-2-yl] oxyethanesulfonic acid) incorporated into the shell is presented. The nanocarriers were formed via the layer-by-layer technique with biodegradable polyelectrolytes: PLL (Poly-L-lysine), and with Nafion®: polymer with high 19F content. Before imaging, an MR (magnetic resonance) spectroscopy and T1 and T2 measurements were performed, resulting in values of T2 between 1.3 ms and 3.0 ms, depending on the spectral line. To overcome limitations due to such short T2, the 3D UTE pulse sequence was applied for 19F MR imaging. First Nafion® solutions of various concentrations were measured to check the detection limit of our system for the investigated molecule. Next, the imaging of a phantom containing core-shell nanocapsules was performed to assess the possibility of visualizing their distribution in the samples. Images of Nafion® containing samples with SNR ≥ 5 with acquisition time below 30 min for 19F concentration as low as 1.53 × 10−2 mmol 19F/g of sample, were obtained. This is comparable with the results obtained for molecules, which exhibit more preferable MR characteristics. View Full-Text
Keywords: theranostic nanocarriers; polyelectrolites nanocapsules; imaging; 19F MRI; ultra short echo time; UTE theranostic nanocarriers; polyelectrolites nanocapsules; imaging; 19F MRI; ultra short echo time; UTE
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MDPI and ACS Style

Łopuszyńska, N.; Szczepanowicz, K.; Jasiński, K.; Warszyński, P.; Węglarz, W.P. Effective Detection of Nafion®-Based Theranostic Nanocapsules Through 19F Ultra-Short Echo Time MRI. Nanomaterials 2020, 10, 2127. https://doi.org/10.3390/nano10112127

AMA Style

Łopuszyńska N, Szczepanowicz K, Jasiński K, Warszyński P, Węglarz WP. Effective Detection of Nafion®-Based Theranostic Nanocapsules Through 19F Ultra-Short Echo Time MRI. Nanomaterials. 2020; 10(11):2127. https://doi.org/10.3390/nano10112127

Chicago/Turabian Style

Łopuszyńska, Natalia, Krzysztof Szczepanowicz, Krzysztof Jasiński, Piotr Warszyński, and Władysław P. Węglarz 2020. "Effective Detection of Nafion®-Based Theranostic Nanocapsules Through 19F Ultra-Short Echo Time MRI" Nanomaterials 10, no. 11: 2127. https://doi.org/10.3390/nano10112127

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